Fibrosis — A Common Pathway to Organ Injury and Failure | New England Journal of Medicine
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Inflammation is one of the most characteristic features of chronic liver disease of viral,
alcoholic, fatty, and autoimmune origin. Inflammation is typically present in all disease …

Fibrosis is a pathological feature of most chronic inflammatory diseases. Fibrosis, or
scarring, is defined by the accumulation of excess extracellular matrix components. If highly …

Liver regeneration has been studied for many decades and the mechanisms underlying
regeneration of the normal liver following resection or moderate damage are well described …

Fibrosis is an intrinsic response to chronic injury, maintaining organ integrity when extensive
necrosis or apoptosis occurs. With protracted damage, fibrosis can progress toward …

Liver fibrosis represents a health problem with significant morbidity and mortality that affects
100 million people worldwide. It is a final pathway to several chronic liver diseases and is …

Substantial improvements in the treatment of chronic liver disease have accelerated interest
in uncovering the mechanisms underlying hepatic fibrosis and its resolution. Activation of …

The management of hepatocellular carcinoma (HCC) has substantially changed in the past
few decades. Improvements in patient stratification (for example, using the Barcelona Clinic …

Liver damage leads to an inflammatory response and to the activation and proliferation of
mesenchymal cell populations within the liver which remodel the extracellular matrix as part …

Background & Aims: Chronic alcohol drinking accelerates liver fibrosis in patients with viral
hepatitis that cannot be fully explained by ethanol-enhanced liver damage. Here, we …