The 2022 Nucleic Acids Research database issue and the online molecular biology database collection
DJ Rigden, XM Fernández - Nucleic acids research, 2022 - academic.oup.com
Abstract The 2022 Nucleic Acids Research Database Issue contains 185 papers, including
87 papers reporting on new databases and 85 updates from resources previously published …
87 papers reporting on new databases and 85 updates from resources previously published …
[HTML][HTML] Impact of structural biology and the protein data bank on us fda new drug approvals of low molecular weight antineoplastic agents 2019–2023
Open access to three-dimensional atomic-level biostructure information from the Protein
Data Bank (PDB) facilitated discovery/development of 100% of the 34 new low molecular …
Data Bank (PDB) facilitated discovery/development of 100% of the 34 new low molecular …
[PDF][PDF] RCSB Protein Data Bank: supporting research and education worldwide through explorations of experimentally determined and computationally predicted …
The Protein Data Bank (PDB) was established as the first open-access digital data resource
in biology and medicine in 1971 with seven X-ray crystal structures of proteins. Today, the …
in biology and medicine in 1971 with seven X-ray crystal structures of proteins. Today, the …
[HTML][HTML] CryoEM structures reveal how the bacterial flagellum rotates and switches direction
Bacterial chemotaxis requires bidirectional flagellar rotation at different rates. Rotation is
driven by a flagellar motor, which is a supercomplex containing multiple rings. Architectural …
driven by a flagellar motor, which is a supercomplex containing multiple rings. Architectural …
[HTML][HTML] CryoEM grid preparation: a closer look at advancements and impact of preparation mode and new approaches
IJ Hirst, WJR Thomas, RA Davies… - Biochemical Society …, 2024 - portlandpress.com
Sample preparation can present a significant hurdle within single particle cryo-electron
microscopy (cryoEM), resulting in issues with reproducibility, data quality or an inability to …
microscopy (cryoEM), resulting in issues with reproducibility, data quality or an inability to …
Tilt-series-based joint CTF estimation for cryo-electron tomography
R Zhang, Y Shen, X Li - Structure, 2024 - cell.com
Contrast transfer function (CTF) estimation is a necessary step in the cryo-electron
tomography (cryoET) workflow and essential for high-resolution in situ structural …
tomography (cryoET) workflow and essential for high-resolution in situ structural …
[HTML][HTML] Outcomes of the EMDataResource Cryo-EM Ligand Modeling Challenge
CL Lawson, A Kryshtafovych, GD Pintilie… - Research …, 2024 - ncbi.nlm.nih.gov
Abstract The EMDataResource Ligand Model Challenge aimed to assess the reliability and
reproducibility of modeling ligands bound to protein and protein/nucleic-acid complexes in …
reproducibility of modeling ligands bound to protein and protein/nucleic-acid complexes in …
CowScape: Quantitative reconstruction of the conformational landscape of biological macromolecules from cryo-EM data
F Lambrecht, A Kröpelin, M Lüttich, M Habeck… - arXiv preprint arXiv …, 2024 - arxiv.org
Cryo-EM data processing typically focuses on the structure of the main conformational state
under investigation and discards images that belong to other states. This approach can …
under investigation and discards images that belong to other states. This approach can …
Outcomes of the EMDataResource Cryo-EM Ligand Modeling Challenge
Abstract The EMDataResource Ligand Model Challenge aimed to assess the reliability and
reproducibility of modeling ligands bound to protein and protein/nucleic-acid complexes in …
reproducibility of modeling ligands bound to protein and protein/nucleic-acid complexes in …