Zebrafish Models of Rare Neurological Diseases like Spinocerebellar Ataxias (SCAs): Advantages and Limitations

S Sarasamma, A Karim, JP Orengo - Biology, 2023 - mdpi.com
Simple Summary Zebrafish can be used as an effective model for studying various genetic
neurological disorders, such as spinocerebellar ataxias. They are cost effective, easy to …

Effect of Enriched Environment on Cerebellum and Social Behavior of Valproic Zebrafish

B Flores-Prieto, F Caycho-Salazar, J Manzo… - NeuroSci, 2024 - mdpi.com
The etiology of autism spectrum disorder (ASD) has been linked to both genetic and
epigenetic factors. Among the epigenetic factors, exposure to valproic acid (VPA), an …

[HTML][HTML] Cerebellar Purkinje Cells Control Posture in Larval Zebrafish (Danio rerio)

F Auer, K Nardone, K Matsuda, M Hibi, D Schoppik - bioRxiv, 2023 - ncbi.nlm.nih.gov
Cerebellar dysfunction leads to postural instability. Recent work in freely moving rodents has
transformed investigations of cerebellar contributions to posture. However, the combined …

Long-term exposure to dimefluthrin inhibits the growth of Acrossocheilus fasciatus

J Huang, H Tong, B Gao, Y Wu, W Li, P Xiao - Environmental Research, 2024 - Elsevier
Dimefluthrin (DIM) is a synthetic pyrethroid insecticide commonly used for the control of
pests, particularly for mosquitoes and other flying insects. However, the effects of DIM on …

Clinical and Molecular Spectrum of Autosomal Recessive CA8‐Related Cerebellar Ataxia

R Kaiyrzhanov, JD Ortigoza‐Escobar… - Movement …, 2024 - Wiley Online Library
Background Based on a limited number of reported families, biallelic CA8 variants have
currently been associated with a recessive neurological disorder named, cerebellar ataxia …

A functional schizophrenia-associated genetic variant near the TSNARE1 and ADGRB1 genes

MH Wahbeh, RJ Boyd, C Yovo, B Rike… - Human Genetics and …, 2024 - cell.com
Recent collaborative genome-wide association studies (GWAS) have identified> 200
independent loci contributing to risk for schizophrenia (SCZ). The genes closest to these loci …

Ionic conductances driving tonic firing in Purkinje neurons of larval zebrafish

MP Jadhav, V Thirumalai - bioRxiv, 2023 - biorxiv.org
Purkinje neurons are the principal neuronal types in the cerebellum, which is among the
oldest and most conserved regions of the vertebrate brain. In mammals and in larval …

GABA-immunoreactive neurons in the Central Nervous System of the viviparous teleost Poecilia sphenops

A Hotha, CB Ganesh - Journal of Chemical Neuroanatomy, 2023 - Elsevier
Gamma-aminobutyric acid (GABA) functions as the primary inhibitory neurotransmitter within
the central nervous system (CNS) of vertebrates. In this study, we examined the distribution …

RFC1 regulates the expansion of neural progenitors in the developing zebrafish cerebellum

F Nobilleau, S Audet, S Turk, C Zaouter, M Liao… - bioRxiv, 2024 - biorxiv.org
DNA replication and repair are basic yet essential molecular processes for all cells. RFC1
encodes the largest subunit of the Replication Factor C (RFC), which is a clamp-loader …