Circulating tumor cell (CTC)-based liquid biopsies provide unique opportunities for cancer
diagnostics, treatment selection, and response monitoring, but even with advanced …

Metastases represent the end products of a multistep cell-biological process termed the
invasion-metastasis cascade, which involves dissemination of cancer cells to anatomically …

It has been hypothesized that carcinoma metastasis is initiated by a subpopulation of
circulating tumor cells (CTCs) found in the blood of patients. However, although the …

Anoikis is a critical obstacle to cancer metastasis. Colorectal cancer (CRC) exhibits a high
rate of metastasis, leading to death, and the mechanisms involved in anoikis resistance are …

Membrane bound vesicles, including microvesicles and exosomes, are secreted by both
normal and cancerous cells into the extracellular space and in blood circulation. These …

The ability to isolate and analyze rare circulating tumor cells (CTCs) has the potential to
further our understanding of cancer metastasis and enhance the care of cancer patients. In …

Kindred cells can have different genomes because of dynamic changes in DNA. Single-cell
sequencing is needed to characterize these genomic differences but has been hindered by …

Interactions of cancer cells with the primary tumor microenvironment are important
determinants of cancer progression toward metastasis but it is unknown whether additional …

The development of cell membrane-modified biomimetic nanoparticles has extensively
increased during the past years due to their exceptional biocompatibility, evasion from the …

Circulating tumor cells (CTCs) are shed into the bloodstream from primary and metastatic
tumor deposits. Their isolation and analysis hold great promise for the early detection of …