Fibrosis, defined by the excess deposition of structural and matricellular proteins in the
extracellular space, underlies tissue dysfunction in multiple chronic diseases. Approved …

Myocardial fibrosis is a significant pathological basis of heart failure. Overactivation of the
ERK1/2 and JNK1/2 signaling pathways of MAPK family members synergistically promotes …

The genetic and genomic basis of sex differences in blood pressure (BP) traits remain
unstudied at scale. Here, we conducted sex-stratified and combined-sex genome-wide …

Leveraging genetics insights to promote drug repurposing has become a promising and
active strategy in pharmacology. Indeed, among the 50 drugs approved by FDA in 2021, two …

Cardiovascular ageing is a process that begins early in life and leads to a progressive
change in structure and decline in function due to accumulated damage across diverse cell …

Abstract Background and Aims Clonal haematopoiesis of indeterminate potential (CHIP), the
age-related expansion of blood cells with preleukemic mutations, is associated with …

Cardiac blood flow is a critical determinant of human health. However, the definition of its
genetic architecture is limited by the technical challenge of capturing dynamic flow volumes …

Fibrotic diseases affect multiple organs and are associated with morbidity and mortality. To
examine organ-specific and shared biologic mechanisms that underlie fibrosis in different …

Diastole is the sequence of physiological events that occur in the heart during ventricular
filling and principally depends on myocardial relaxation and chamber stiffness. Abnormal …

The extracellular matrix (ECM) determines functional properties of connective tissues
through structural components, such as collagens, elastic fibers, or proteoglycans. The ECM …