Pancreatic cancer models for translational research
D Behrens, W Walther, I Fichtner - Pharmacology & therapeutics, 2017 - Elsevier
Pancreatic cancer is a cruel, progressive disease that is highly metastatic and barely
treatable, a situation that is devastating for patients, family members, oncologists, clinicians …
treatable, a situation that is devastating for patients, family members, oncologists, clinicians …
Animal models: challenges and opportunities to determine optimal experimental models of pancreatitis and pancreatic cancer
At the 2018 PancreasFest meeting, experts participating in basic research met to discuss the
plethora of available animal models for studying exocrine pancreatic disease. In particular …
plethora of available animal models for studying exocrine pancreatic disease. In particular …
The advanced glycation end‐product Nϵ‐carboxymethyllysine promotes progression of pancreatic cancer: implications for diabetes‐associated risk and its …
S Menini, C Iacobini, L de Latouliere… - The Journal of …, 2018 - Wiley Online Library
Diabetes is an established risk factor for pancreatic cancer (PaC), together with obesity, a
Western diet, and tobacco smoking. The common mechanistic link might be the …
Western diet, and tobacco smoking. The common mechanistic link might be the …
[HTML][HTML] Role of stromal activin A in human pancreatic cancer and metastasis in mice
Pancreatic ductal adenocarcinoma (PDAC) has extensive stromal involvement and remains
one of the cancers with the highest mortality rates. Activin A has been implicated in colon …
one of the cancers with the highest mortality rates. Activin A has been implicated in colon …
[HTML][HTML] Diabetes promotes invasive pancreatic cancer by increasing systemic and tumour carbonyl stress in KrasG12D/+ mice
S Menini, C Iacobini, L de Latouliere, I Manni… - Journal of Experimental …, 2020 - Springer
Background Type 1 and 2 diabetes confer an increased risk of pancreatic cancer (PaC) of
similar magnitude, suggesting a common mechanism. The recent finding that PaC incidence …
similar magnitude, suggesting a common mechanism. The recent finding that PaC incidence …
The RNA‐binding protein MEX3A is a prognostic factor and regulator of resistance to gemcitabine in pancreatic ductal adenocarcinoma
V Panzeri, I Manni, A Capone, C Naro… - Molecular …, 2021 - Wiley Online Library
Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive cancer. Most patients
present with advanced disease at diagnosis, which only permits palliative chemotherapeutic …
present with advanced disease at diagnosis, which only permits palliative chemotherapeutic …
[HTML][HTML] Transgenic animal models to visualize cancer-related cellular processes by bioluminescence imaging
I Manni, L De Latouliere, A Gurtner… - Frontiers in …, 2019 - frontiersin.org
Preclinical animal models are valuable tools to improve treatments of malignant diseases,
being an intermediate step of experimentation between cell culture and human clinical trials …
being an intermediate step of experimentation between cell culture and human clinical trials …
Advancements in Preclinical Models of Pancreatic Cancer
Pancreatic cancer remains one of the deadliest of all cancer types with a 5-year overall
survival rate of just 12%. Preclinical models available for understanding the disease …
survival rate of just 12%. Preclinical models available for understanding the disease …
Four-class tumor staging for early diagnosis and monitoring of murine pancreatic cancer using magnetic resonance and ultrasound
E Dugnani, V Pasquale, P Marra, D Liberati… - …, 2018 - academic.oup.com
Background The widely used genetically engineered mouse LSL-Kras G12D/+; LSL-Trp53
R172H/+; Pdx-1-Cre, termed KPC, spontaneously develops pancreatic cancer mirroring all …
R172H/+; Pdx-1-Cre, termed KPC, spontaneously develops pancreatic cancer mirroring all …
[HTML][HTML] Development of two mouse strains conditionally expressing bright luciferases with distinct emission spectra as new tools for in vivo imaging
T Nakashiba, K Ogoh, S Iwano, T Sugiyama… - Lab Animal, 2023 - nature.com
In vivo bioluminescence imaging (BLI) has been an invaluable noninvasive method to
visualize molecular and cellular behaviors in laboratory animals. Bioluminescent reporter …
visualize molecular and cellular behaviors in laboratory animals. Bioluminescent reporter …