Mechanisms and pathology of protein misfolding and aggregation

N Louros, J Schymkowitz, F Rousseau - Nature Reviews Molecular Cell …, 2023 - nature.com
Despite advances in machine learning-based protein structure prediction, we are still far
from fully understanding how proteins fold into their native conformation. The conventional …

Gut microbiome–brain alliance: a landscape view into mental and gastrointestinal health and disorders

JM Sasso, RM Ammar, R Tenchov… - ACS Chemical …, 2023 - ACS Publications
Gut microbiota includes a vast collection of microorganisms residing within the
gastrointestinal tract. It is broadly recognized that the gut and brain are in constant …

Emerging role of the host microbiome in neuropsychiatric disorders: overview and future directions

K Hashimoto - Molecular Psychiatry, 2023 - nature.com
The human body harbors a diverse ecosystem of microorganisms, including bacteria,
viruses, and fungi, collectively known as the microbiota. Current research is increasingly …

[HTML][HTML] Correlation between the gut microbiome and neurodegenerative diseases: a review of metagenomics evidence

X Liu, Y Liu, J Liu, H Zhang, C Shan… - Neural Regeneration …, 2024 - journals.lww.com
A growing body of evidence suggests that the gut microbiota contributes to the development
of neurodegenerative diseases via the microbiota-gut-brain axis. As a contributing factor …

Therapeutics for neurodegenerative diseases by targeting the gut microbiome: from bench to bedside

YY Ma, X Li, JT Yu, YJ Wang - Translational Neurodegeneration, 2024 - Springer
The aetiologies and origins of neurodegenerative diseases, such as Alzheimer's disease
(AD), Parkinson's disease (PD), amyotrophic lateral sclerosis (ALS) and Huntington's …

Walnut-Derived Peptide Improves Cognitive Impairment in Colitis Mice Induced by Dextran Sodium Sulfate via the Microbiota–Gut–Brain Axis (MGBA)

Y Qi, X Wang, Y Zhang, Y Leng, X Liu… - Journal of Agricultural …, 2023 - ACS Publications
In this study, we investigated the protective mechanism of walnut-derived peptide LPLLR
(LP-5) against cognitive impairment induced in a dextran sodium sulfate (DSS)-induced …

Implicative role of cytokines in neuroinflammation mediated AD and associated signaling pathways: Current progress in molecular signaling and therapeutics

S Kumari, R Dhapola, P Sharma, SK Singh… - Ageing Research …, 2023 - Elsevier
Alzheimer's Disease (AD) is one of the most devastating age-related disorder causing
significant social and economic burden worldwide. It affects the cognitive and social …

[HTML][HTML] Slow gut transit increases the risk of Alzheimer's disease: an integrated study of the bi-national cohort in South Korea and Japan and Alzheimer's disease …

J Kang, M Lee, M Park, J Lee, S Lee, J Park… - Journal of Advanced …, 2023 - Elsevier
Introduction Although the association between Alzheimer's disease (AD) and constipation is
controversial, its causality and underlying mechanisms remain unknown. Objectives To …

Do microbes play a role in Alzheimer's disease?

ZAP Williams, L Lang, S Nicolas, G Clarke… - Microbial …, 2024 - Wiley Online Library
Alzheimer's disease is a complex and progressive condition that affects essential
neurological functions such as memory and reasoning. In the brain, neuronal loss, synaptic …

The gastrointestinal microbiota in the development of ME/CFS: a critical view and potential perspectives

A Stallmach, S Quickert, C Puta… - Frontiers in Immunology, 2024 - frontiersin.org
Like other infections, a SARS-CoV-2 infection can also trigger Post-Acute Infection
Syndromes (PAIS), which often progress into myalgic encephalomyelitis/chronic fatigue …