[HTML][HTML] β-Caryophyllene: a sesquiterpene with countless biological properties

F Francomano, A Caruso, A Barbarossa, A Fazio… - Applied sciences, 2019 - mdpi.com
β-Caryophyllene (BCP), a natural bicyclic sesquiterpene, is a selective phytocannabinoid
agonist of type 2 receptors (CB2-R). It isn't psychogenic due to the absence of an affinity to …

Medicinal properties of terpenes found in Cannabis sativa and Humulus lupulus

T Nuutinen - European journal of medicinal chemistry, 2018 - Elsevier
Cannabaceae plants Cannabis sativa L. and Humulus lupulus L. are rich in terpenes–both
are typically comprised of terpenes as up to 3–5% of the dry-mass of the female …

[HTML][HTML] Protective Effects of (E)-β-Caryophyllene (BCP) in Chronic Inflammation

R Scandiffio, F Geddo, E Cottone, G Querio… - Nutrients, 2020 - mdpi.com
(E)-β-caryophyllene (BCP) is a bicyclic sesquiterpene widely distributed in the plant
kingdom, where it contributes a unique aroma to essential oils and has a pivotal role in the …

Citrus medica: nutritional, phytochemical composition and health benefits–a review

N Chhikara, R Kour, S Jaglan, P Gupta, Y Gat… - Food & function, 2018 - pubs.rsc.org
Citrus medica (Citron) is an underutilized fruit plant having various bioactive components in
all parts of the plant. The major bioactive compounds present are iso-limonene, citral …

[HTML][HTML] Neuroprotective effects of black pepper cold-pressed oil on scopolamine-induced oxidative stress and memory impairment in rats

NM Mostafa, AM Mostafa, ML Ashour, SS Elhady - Antioxidants, 2021 - mdpi.com
Oxidative stress is usually associated with many neurodegenerative diseases. In this study,
the gas chromatography–mass spectrometry (GC–MS) analysis of cold-pressed oil (CPO) …

[HTML][HTML] Terpenoids as potential geroprotectors

E Proshkina, S Plyusnin, T Babak, E Lashmanova… - Antioxidants, 2020 - mdpi.com
Terpenes and terpenoids are the largest groups of plant secondary metabolites. However,
unlike polyphenols, they are rarely associated with geroprotective properties. Here we …

Natural products as a potential modulator of microglial polarization in neurodegenerative diseases

X Jin, MY Liu, DF Zhang, X Zhong, K Du, P Qian… - Pharmacological …, 2019 - Elsevier
abstract Neurodegenerative diseases (NDs) are characterized by the progressive loss of
structure and function of neurons most common in elderly population, mainly including …

CB2 receptor in the CNS: From immune and neuronal modulation to behavior

W Grabon, S Rheims, J Smith, J Bodennec… - Neuroscience & …, 2023 - Elsevier
Despite low levels of cannabinoid receptor type 2 (CB2R) expression in the central nervous
system in human and rodents, a growing body of evidence shows CB2R involvement in …

A systematic review on the neuroprotective perspectives of beta‐caryophyllene

KC Machado, MT Islam, ES Ali, R Rouf… - Phytotherapy …, 2018 - Wiley Online Library
Beta (β)‐caryophyllene (BCAR) is a major sesquiterpene of various plant essential oils
reported for several important pharmacological activities, including antioxidant, anti …

A mechanistic review on immunomodulatory effects of selective type two cannabinoid receptor β‐caryophyllene

V Baradaran Rahimi, VR Askari - Biofactors, 2022 - Wiley Online Library
Abstract β‐Caryophyllene (BCP) is a plant‐derived compound and occurs naturally in
various foods and spices, including cinnamon, citrus, fruits, clove, curry, and pepper. BCP …