Highlights•Self-contained overview of current high-throughput screening technologies.•
Expands on the current use of most recent tools, like high-throughput microscopy.•Learn …

Highlights•Traditional drug screening model systems are inadequate.•Organoid-on-a-chip
platforms stand to significantly advance drug and toxicology screening.•A wide variety or …

Drug-induced liver injury (DILI) is a patient-specific, temporal, multifactorial
pathophysiological process that cannot yet be recapitulated in a single in vitro model …

Accurate prediction of the adverse effects of test compounds on living systems, detection of
toxic thresholds, and expansion of experimental data sets to include multiple toxicity end …

The high global incidence of cancer is associated with high rates of mortality and morbidity
worldwide. By taking advantage of the properties of matter at the nanoscale, nanomedicine …

This paper describes the development and characterization of a microphysiology platform
for drug safety and efficacy in liver models of disease that includes a human, 3D …

Nucleoside analogs represent the largest class of small molecule-based antivirals, which
currently form the backbone of chemotherapy of chronic infections caused by HIV, hepatitis …

The liver is one of the largest organs in the body and is responsible for a diverse repertoire
of metabolic processes. Such processes include the secretion of serum proteins …

We used 3D cell printing to emulate an airway coupled with a naturally-derived blood vessel
network in vitro. Decellularized extracellular matrix bioink derived from porcine tracheal …

Organ-on-a-chip (OOC) is a very ambitious emerging technology with a high potential to
revolutionize many medical and industrial sectors, particularly in preclinical-to-clinical …