Diagnostic and therapeutic implications of ex vivo lung perfusion in lung transplantation: potential benefits and inherent limitations

J Yu, N Zhang, Z Zhang, Y Li, J Gao, C Chen… - Transplantation, 2023 - journals.lww.com
Ex vivo lung perfusion (EVLP), a technique in which isolated lungs are continually ventilated
and perfused at normothermic temperature, is emerging as a promising platform to optimize …

[HTML][HTML] Insights into the role of the Wnt signaling pathway in the regeneration of animal model systems

KS Walczyńska, L Zhu, Y Liang - The International Journal of …, 2023 - ijdb.ehu.eus
Regeneration enables the regrowth and restoration of missing body parts. It is a common
phenomenon among animals. However, only some species exhibit remarkable regeneration …

Delivery of Therapeutics to Solid Organs Using Ex Vivo Machine Perfusion

M Mendiola Pla, DE Bowles - Drug Discovery and Evaluation: Safety and …, 2023 - Springer
The use of ex vivo machine perfusion for organ preservation has significantly improved solid
organ transplantation outcomes. This modality of organ preservation has increased the …

Challenges With the Implementation of Machine Perfusion in Clinical Liver Transplantation

FHC De Goeij, V De Meijer, H Mergental… - …, 2024 - journals.lww.com
Dynamic organ preservation is a relatively old technique which has regained significant
interest in the last decade. Machine perfusion (MP) techniques are applied in various fields …

Macrophage‐derived extracellular vesicles alter cardiac recovery and metabolism in a rat heart model of donation after circulatory death

S Graf, V Biemmi, M Arnold, A Segiser… - Journal of Cellular …, 2024 - Wiley Online Library
Conditions to which the cardiac graft is exposed during transplantation with donation after
circulatory death (DCD) can trigger the recruitment of macrophages that are either …

[HTML][HTML] State-of-the-Art and Future Directions in Organ Regeneration with Mesenchymal Stem Cells and Derived Products during Dynamic Liver Preservation

N De Stefano, A Calleri, V Navarro-Tableros, F Rigo… - Medicina, 2022 - mdpi.com
Transplantation is currently the treatment of choice for end-stage liver diseases but is
burdened by the shortage of donor organs. Livers from so-called extended-criteria donors …

Potassium canrenoate in brain-dead organ donors: a randomised controlled clinical trial protocol (CANREO-PMO)

L Belarif, S Girerd, F Jaisser, X Lepage, L Merckle… - BMJ open, 2023 - bmjopen.bmj.com
Introduction Ischaemia/reperfusion injuries (IRIs) are associated with poorer survival of
kidney grafts from expanded criteria donors. Preclinical studies have shown that …

Mesenchymal Stem Cells as an Adjuvant Tool to Induce Regeneration and Repair in Marginal Renal Allografts

JR Savino, AR Monetti, JB Miller, JJ Bowlby… - Current Transplantation …, 2023 - Springer
Abstract Purpose of Review Mesenchymal stem cells (MSC) have been largely studied for
more than three decades and have been proposed to treat a myriad of clinical conditions in …