Genomic findings in schizophrenia and their implications
There has been substantial progress in understanding the genetics of schizophrenia over
the past 15 years. This has revealed a highly polygenic condition with the majority of the …
the past 15 years. This has revealed a highly polygenic condition with the majority of the …
Modeling psychotic disorders: environment x environment interaction
K Murlanova, MV Pletnikov - Neuroscience & Biobehavioral Reviews, 2023 - Elsevier
Schizophrenia is a major psychotic disorder with multifactorial etiology that includes
interactions between genetic vulnerability and environmental risk factors. In addition …
interactions between genetic vulnerability and environmental risk factors. In addition …
Schizophrenia risk conferred by rare protein-truncating variants is conserved across diverse human populations
D Liu, D Meyer, B Fennessy, C Feng, E Cheng… - Nature …, 2023 - nature.com
Schizophrenia (SCZ) is a chronic mental illness and among the most debilitating conditions
encountered in medical practice. A recent landmark SCZ study of the protein-coding regions …
encountered in medical practice. A recent landmark SCZ study of the protein-coding regions …
Penetrance and pleiotropy of polygenic risk scores for schizophrenia, bipolar disorder, and depression among adults in the US veterans affairs health care system
Importance Serious mental illnesses, including schizophrenia, bipolar disorder, and
depression, are heritable, highly multifactorial disorders and major causes of disability …
depression, are heritable, highly multifactorial disorders and major causes of disability …
Neurobiological, familial and genetic risk factors for dimensional psychopathology in the Adolescent Brain Cognitive Development study
Background Adolescence is a key period for brain development and the emergence of
psychopathology. The Adolescent Brain Cognitive Development (ABCD) study was created …
psychopathology. The Adolescent Brain Cognitive Development (ABCD) study was created …
A novel multi-class classification model for schizophrenia, bipolar disorder and healthy controls using comprehensive transcriptomic data
Q Yang, Y Li, B Li, Y Gong - Computers in Biology and Medicine, 2022 - Elsevier
Two common psychiatric disorders, schizophrenia (SCZ) and bipolar disorder (BP), confer
lifelong disability and collectively affect 2% of the world population. Because the diagnosis …
lifelong disability and collectively affect 2% of the world population. Because the diagnosis …
The genetic relationships between brain structure and schizophrenia
Genetic risks for schizophrenia are theoretically mediated by genetic effects on brain
structure but it has been unclear which genes are associated with both schizophrenia and …
structure but it has been unclear which genes are associated with both schizophrenia and …
Identifying novel proteins underlying schizophrenia via integrating pQTLs of the plasma, CSF, and brain with GWAS summary data
Background Schizophrenia (SCZ) is a chronic and severe mental illness with no cure so far.
Mendelian randomization (MR) is a genetic method widely used to explore etiologies of …
Mendelian randomization (MR) is a genetic method widely used to explore etiologies of …
[HTML][HTML] Lessons learned from parsing genetic risk for schizophrenia into biological pathways
The clinically heterogeneous presentation of schizophrenia is compounded by the
heterogeneity of risk factors and neurobiological correlates of the disorder. Genome-wide …
heterogeneity of risk factors and neurobiological correlates of the disorder. Genome-wide …
Genes implicated by a methylome-wide schizophrenia study in neonatal blood show differential expression in adult brain samples
EJCG van den Oord, LY Xie, M Zhao… - Molecular …, 2023 - nature.com
Schizophrenia is a disabling disorder involving genetic predisposition in combination with
environmental influences that likely act via dynamic alterations of the epigenome and the …
environmental influences that likely act via dynamic alterations of the epigenome and the …