New insight on microglia activation in neurodegenerative diseases and therapeutics

Y Xu, W Gao, Y Sun, M Wu - Frontiers in Neuroscience, 2023 - frontiersin.org
Microglia are immune cells within the central nervous system (CNS) closely linked to brain
health and neurodegenerative diseases such as Alzheimer's disease and Parkinson's …

[HTML][HTML] Progress in Parkinson's disease animal models of genetic defects: Characteristics and application

C Zhang, S Chen, X Li, Q Xu, Y Lin, F Lin… - Biomedicine & …, 2022 - Elsevier
Parkinson's disease (PD) is the second major progressive neurodegenerative disease,
which critically impacts patients' quality of life. Based on genetics, animal models of genetic …

Resveratrol inhibits autophagy against myocardial ischemia-reperfusion injury through the DJ-1/MEKK1/JNK pathway

S Liu, J Ren, S Liu, X Zhao, H Liu, T Zhou… - European Journal of …, 2023 - Elsevier
Resveratrol (RES), a natural polyphenolic compound found in red wine and grape skins, has
attracted significant attention due to its cardioprotective properties. DJ-1, a multifunctional …

Loss of DJ-1 function contributes to Parkinson's disease pathogenesis in mice via RACK1-mediated PKC activation and MAO-B upregulation

L Liu, Y Han, Z Zhang, Y Wang, Y Hu… - Acta Pharmacologica …, 2023 - nature.com
Parkinson's disease (PD) is a common neurodegenerative motor disorder characterized by
a dramatic reduction in pars compacta of substantia nigra dopaminergic neurons and striatal …

A TaSnRK1α Modulates TaPAP6L‐Mediated Wheat Cold Tolerance through Regulating Endogenous Jasmonic Acid

L Zhang, N Zhang, S Wang, H Tian, L Liu… - Advanced …, 2023 - Wiley Online Library
Here, a sucrose non‐fermenting‐1‐related protein kinase alpha subunit (TaSnRK1α‐1A) is
identified as associated with cold stress through integration of genome‐wide association …

Cannabidiol Protects Dopaminergic-like Neurons against Paraquat- and Maneb-Induced Cell Death through Safeguarding DJ-1CYS106 and Caspase 3 …

M Mendivil-Perez, AA Felizardo-Otalvaro… - ACS Chemical …, 2023 - ACS Publications
Parkinson's disease (PD), a progressive neurodegenerative movement disorder, has
reached pandemic status worldwide. This neurologic disorder is caused primarily by the …

Irradiation induces DJ-1 secretion from esophageal squamous cell carcinoma cells to accelerate metastasis of bystander cells via a TGF-β1 positive feedback loop

J Gu, Y Sun, J Song, R Zhao, X Di, Y Zhang… - Journal of Experimental …, 2022 - Springer
Background Radiation-induced bystander effect (RIBE) can promote tumor metastasis
contributing to the failure of radiotherapy for esophageal squamous cell carcinoma (ESCC) …

Inhibition by pesticides of the DJ-1/Park7 protein related to Parkinson disease.

N Mathas, G Poncet, C Laurent, L Larigot, B Le-Grand… - Toxicology, 2023 - Elsevier
Parkinson's disease is a severe neurodegenerative disease. Several environmental
contaminants such as pesticides have been suspected to favor the appearance of this …

Riboflavin protects against heart failure via SCAD‐dependent DJ‐1–Keap1–Nrf2 signalling pathway

Q Xu, Y Cao, X Zhong, X Qin, J Feng… - British journal of …, 2023 - Wiley Online Library
Abstract Background and Purpose Our recent studies have shown that flavin adenine
dinucleotide (FAD) exerts cardiovascular protective effects by supplementing short‐chain …

[HTML][HTML] 小胶质细胞及其介导的神经炎症在帕金森病中的作用

朱睿放, 张宇, 卢应梅 - 南京医科大学学报(自然科学版), 2023 - jnmu.njmu.edu.cn
摘要随着社会老龄化进程加快, 帕金森病(Parkinson's disease, PD) 的患病率呈上升趋势.
近年来大量证据表明神经炎症在PD 进展中起到了重要作用, 尤其在PD 病理学相关的基底神经 …