[HTML][HTML] Injectable hydrogels: An emerging therapeutic strategy for cartilage regeneration

A Atwal, TP Dale, M Snow, NR Forsyth… - Advances in colloid and …, 2023 - Elsevier
The impairment of articular cartilage due to traumatic incidents or osteoarthritis has posed
significant challenges for healthcare practitioners, researchers, and individuals suffering …

Extracellular vesicles derived from mesenchymal stem cells—a novel therapeutic tool in infectious diseases

T Manzoor, A Saleem, N Farooq, LA Dar… - Inflammation and …, 2023 - Springer
Extracellular vesicles (EVs) are nano-sized lipid-bilayer encapsulated vesicles produced by
the cells. These EVs are released into the surrounding space by almost all cell types. The …

Thermosensitive hydrogel loaded with primary chondrocyte-derived exosomes promotes cartilage repair by regulating macrophage polarization in osteoarthritis

X Sang, X Zhao, L Yan, X Jin, X Wang, J Wang… - Tissue engineering and …, 2022 - Springer
BACKGROUND: Intra-articular injection is a classic strategy for the treatment of early
osteoarthritis (OA). However, the local delivery of traditional therapeutic agents has limited …

Cd10-Bound human mesenchymal stem/stromal cell-derived small extracellular vesicles possess immunomodulatory cargo and maintain cartilage homeostasis under …

D Kouroupis, LD Kaplan, J Huard, TM Best - Cells, 2023 - mdpi.com
The onset and progression of human inflammatory joint diseases are strongly associated
with the activation of resident synovium/infrapatellar fat pad (IFP) pro-inflammatory and pain …

Current understanding of MSC-derived exosomes in the management of knee osteoarthritis

M Jeyaraman, S Muthu, S Shehabaz… - Experimental Cell …, 2022 - Elsevier
Mesenchymal stem cell-derived exosomes (MSC-Exos) have been utilized as medicinal
agents or as delivery vehicles in cartilage injuries and cartilage-based diseases. Given the …

[HTML][HTML] A static magnetic field enhances the repair of osteoarthritic cartilage by promoting the migration of stem cells and chondrogenesis

Y Sun, Y Fang, X Li, J Li, D Liu, M Wei, Z Liao… - Journal of Orthopaedic …, 2023 - Elsevier
Objective To investigate the therapeutic effects of static magnetic field (SMF) and its
regulatory mechanism in the repair of osteoarthritic cartilage. Methods Fourteen-week-old …

Cytokine-primed umbilical cord mesenchymal stem cells enhanced therapeutic effects of extracellular vesicles on osteoarthritic chondrocytes

TH Nguyen, HH Dao, CM Duong, XH Nguyen… - Frontiers in …, 2022 - frontiersin.org
In recent years, extracellular vesicles (EVs) secreted by mesenchymal stem cells (MSCs)
have emerged as a potential cell-free therapy against osteoarthritis (OA). Thus, we …

Global research trends in extracellular vesicles based on stem cells from 1991 to 2021: A bibliometric and visualized study

J Lin, Z Yang, L Wang, D Xing, J Lin - Frontiers in bioengineering and …, 2022 - frontiersin.org
Objective: With the development of extracellular vesicles (EVs) based on stem cells research
all over the world, our present study was aiming to discover the global trends in this field …

Mesenchymal stromal cells-derived extracellular vesicles as potential treatments for osteoarthritis

S Yuan, G Li, J Zhang, X Chen, J Su, F Zhou - Pharmaceutics, 2023 - mdpi.com
Osteoarthritis (OA) is a degenerative disease of the joints characterized by cartilage damage
and severe pain. Despite various pharmacological and surgical interventions, current …

Age and synovitis affect the results of the treatment of knee osteoarthritis with Microfragmented Autologous Fat Tissue

R Ferracini, M Alessio-Mazzola, B Sonzogni… - Knee Surgery, Sports …, 2023 - Springer
Purpose This study aims to assess the effectiveness of Microfragmented Autologous Fat
Tissue (MFAT) treatment for knee osteoarthritis and to investigate whether patients' pre …