[HTML][HTML] The cellular and physiological basis for lung repair and regeneration: past, present, and future
The respiratory system, which includes the trachea, airways, and distal alveoli, is a complex
multi-cellular organ that intimately links with the cardiovascular system to accomplish gas …
multi-cellular organ that intimately links with the cardiovascular system to accomplish gas …
The effects of sepsis on endothelium and clinical implications
EV Dolmatova, K Wang, R Mandavilli… - Cardiovascular …, 2021 - academic.oup.com
Sepsis accounts for nearly 700 000 deaths in Europe annually and is caused by an
overwhelming host response to infection resulting in organ failure. The endothelium is an …
overwhelming host response to infection resulting in organ failure. The endothelium is an …
[HTML][HTML] Single-cell RNA landscape of the osteoimmunology microenvironment in periodontitis
Y Chen, H Wang, Q Yang, W Zhao, Y Chen, Q Ni… - Theranostics, 2022 - ncbi.nlm.nih.gov
Single-cell RNA sequencing (scRNA-seq) enables specific profiling of cell populations at
single-cell resolution. The osteoimmunology microenvironment in the occurrence and …
single-cell resolution. The osteoimmunology microenvironment in the occurrence and …
Endothelial FoxM1 reactivates aging-impaired endothelial regeneration for vascular repair and resolution of inflammatory lung injury
X Huang, X Zhang, N Machireddy, CE Evans… - Science translational …, 2023 - science.org
Aging is a major risk factor of high incidence and increased mortality of acute respiratory
distress syndrome (ARDS). Here, we demonstrated that persistent lung injury and high …
distress syndrome (ARDS). Here, we demonstrated that persistent lung injury and high …
[HTML][HTML] mtDNA activates cGAS signaling and suppresses the YAP-mediated endothelial cell proliferation program to promote inflammatory injury
Cytosolic DNA acts as a universal danger-associated molecular pattern (DAMP) signal;
however, the mechanisms of self-DNA release into the cytosol and its role in inflammatory …
however, the mechanisms of self-DNA release into the cytosol and its role in inflammatory …
[HTML][HTML] Engineered ACE2 decoy mitigates lung injury and death induced by SARS-CoV-2 variants
Vaccine hesitancy and emergence of severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2) variants of concern (VOCs) escaping vaccine-induced immune responses …
(SARS-CoV-2) variants of concern (VOCs) escaping vaccine-induced immune responses …
[HTML][HTML] IL-1β suppression of VE-cadherin transcription underlies sepsis-induced inflammatory lung injury
Unchecked inflammation is a hallmark of inflammatory tissue injury in diseases such as
acute respiratory distress syndrome (ARDS). Yet the mechanisms of inflammatory lung injury …
acute respiratory distress syndrome (ARDS). Yet the mechanisms of inflammatory lung injury …
A composite solid polymer electrolyte incorporating MnO 2 nanosheets with reinforced mechanical properties and electrochemical stability for lithium metal batteries
A solid polymer electrolyte is expected to be useful for safe and high energy density lithium-
metal batteries owing to its good flexibility and high degree of safety. The development of a …
metal batteries owing to its good flexibility and high degree of safety. The development of a …
[HTML][HTML] Mechanisms of endothelial regeneration and vascular repair and their application to regenerative medicine
CE Evans, ML Iruela-Arispe, YY Zhao - The American journal of pathology, 2021 - Elsevier
Endothelial barrier integrity is required for maintaining vascular homeostasis and fluid
balance between the circulation and surrounding tissues and for preventing the …
balance between the circulation and surrounding tissues and for preventing the …
Computational reconstruction of the signalling networks surrounding implanted biomaterials from single-cell transcriptomics
The understanding of the foreign-body responses to implanted biomaterials would benefit
from the reconstruction of intracellular and intercellular signalling networks in the …
from the reconstruction of intracellular and intercellular signalling networks in the …