Amyloid A amyloidosis is a serious clinical condition resulting from the systemic deposition
of amyloid A originating from serum amyloid A proteins with the kidneys being the most …

Background: Acute respiratory distress syndrome (ARDS) is a respiratory condition caused
by severe endothelial barrier dysfunction within the lung. In ARDS, excessive inflammation …

Acute Lung Injury (ALI) is characterized by widespread inflammation which in its severe
form, Acute Respiratory Distress Syndrome (ARDS), leads to compromise in respiration …

Alcohol-induced osteonecrosis of the femoral head (ONFH) is a disabling disease with a
high incidence and elusive pathogenesis. Here, we used single-cell RNA sequencing to …

Ample evidence pinpoints the phenotypic diversity of blood vessels (BVs) and site-specific
functions of their lining endothelial cells (ECs). We harnessed single-cell RNA sequencing …

Seminiferous tubules (STs) in the mammalian testes are connected to the rete testis (RT) via
a Sertoli valve (SV). Spermatozoa produced in the STs are released into the tubular luminal …

Obstructive sleep apnea (OSA) results from episodes of airway collapse and intermittent
hypoxia (IH) and is associated with a host of health complications. Although the lung is the …

Background Autophagy is activated during the pathogenesis of endothelial dysfunction and
sepsis-associated acute lung injury (ALI). This study aimed to investigate whether …

BACKGROUND: Rare genetic variants and genetic variation at loci in an enhancer in
SOX17 (SRY-box transcription factor 17) are identified in patients with idiopathic pulmonary …

Endothelial cells (EC) are the anatomical boundaries between the intravascular and
extravascular space. Damage to ECs is catastrophic and induces endothelial cell …