The spinal dorsal horn receives input from primary afferent axons, which terminate in a
modality-specific fashion in different laminae. The incoming somatosensory information is …

The exteroceptive somatosensory system is important for reflexive and adaptive behaviors
and for the dynamic control of movement in response to external stimuli. This review outlines …

The dorsal horns of the spinal cord and the trigeminal nuclei in the brainstem contain neuron
populations that are critical to process sensory information. Neurons in these areas are …

Pain is a percept of critical importance to our daily survival. In most cases, it serves both an
adaptive function by helping us respond appropriately in a potentially hostile environment …

A cardinal, intractable symptom of neuropathic pain is mechanical allodynia, pain caused by
innocuous stimuli via low-threshold mechanoreceptors such as Aβ fibers. However, the …

Around a quarter of neurons in laminae I–II of the dorsal horn are inhibitory interneurons.
These play an important role in modulating somatosensory information, including that …

Somatosensory information is processed by a complex network of interneurons in the spinal
dorsal horn. It has been reported that inhibitory interneurons that express neuropeptide Y …

The ability to sense and move within an environment are complex functions necessary for
the survival of nearly all species. The spinal cord is both the initial entry site for peripheral …

Highlights•Single cell sequencing is elucidating neuronal heterogeneity within sensory
circuits.•Transcriptome, morphology, physiology, and connectome underlie functional cell …

Chronic pain is a serious condition that significantly impairs the quality of life, affecting an
estimate of 1.5 billion people worldwide. Despite the physiological, emotional and financial …