[HTML][HTML] Strategies to overcome the main challenges of the use of CRISPR/Cas9 as a replacement for cancer therapy

MF Rasul, BM Hussen, A Salihi, BS Ismael, PJ Jalal… - Molecular Cancer, 2022 - Springer
CRISPR/Cas9 (clustered regularly interspaced short palindromic repeats-associated protein
9) shows the opportunity to treat a diverse array of untreated various genetic and …

CRISPR-Cas9: a preclinical and clinical perspective for the treatment of human diseases

G Sharma, AR Sharma, M Bhattacharya, SS Lee… - Molecular Therapy, 2021 - cell.com
At present, the idea of genome modification has revolutionized the modern therapeutic
research era. Genome modification studies have traveled a long way from gene …

CRISPR/Cas9 in genome editing and beyond

H Wang, M La Russa, LS Qi - Annual review of biochemistry, 2016 - annualreviews.org
The Cas9 protein (CRISPR-associated protein 9), derived from type II CRISPR (clustered
regularly interspaced short palindromic repeats) bacterial immune systems, is emerging as a …

CRISPR/Cas9 genome editing in wheat

D Kim, B Alptekin, H Budak - Functional & integrative genomics, 2018 - Springer
Genome editing has been a long-term challenge for molecular biology research, particularly
for plants possess complex genome. The recently discovered Clustered Regularly …

[HTML][HTML] Construct design for CRISPR/Cas-based genome editing in plants

MM Hassan, Y Zhang, G Yuan, K De, JG Chen… - Trends in Plant …, 2021 - cell.com
CRISPR construct design is a key step in the practice of genome editing, which includes
identification of appropriate Cas proteins, design and selection of guide RNAs (gRNAs), and …

[PDF][PDF] Industri 4.0: Revolusi industri abad ini dan pengaruhnya pada bidang kesehatan dan bioteknologi

RR Tjandrawinata - Jurnal Medicinus, 2016 - researchgate.net
Ekonomi global saat ini sedang pada titik puncak perubahan besar yang sebanding
besarnya dengan munculnya revolusi industri pertama atau perkembangan perakitan …

Simultaneous CRISPR/Cas9‐mediated editing of cassava eIF4E isoforms nCBP‐1 and nCBP‐2 reduces cassava brown streak disease symptom severity and …

MA Gomez, ZD Lin, T Moll, RD Chauhan… - Plant biotechnology …, 2019 - Wiley Online Library
Cassava brown streak disease (CBSD) is a major constraint on cassava yields in East and
Central Africa and threatens production in West Africa. CBSD is caused by two species of …

Viral delivery systems for CRISPR

CL Xu, MZC Ruan, VB Mahajan, SH Tsang - Viruses, 2019 - mdpi.com
The frontiers of precision medicine have been revolutionized by the development of
Clustered Regularly-Interspaced Short Palindromic Repeats (CRISPR)/Cas9 as an editing …

Editing of the Bacillus subtilis genome by the CRISPR-Cas9 system

J Altenbuchner - Applied and environmental microbiology, 2016 - Am Soc Microbiol
The clustered regularly interspaced short palindromic repeat (CRISPR)-associated (Cas)
systems are adaptive immune systems of bacteria. A type II CRISPR-Cas9 system from …

CRISPR ethics: moral considerations for applications of a powerful tool

C Brokowski, M Adli - Journal of molecular biology, 2019 - Elsevier
With the emergence of CRISPR technology, targeted editing of a wide variety of genomes is
no longer an abstract hypothetical, but occurs regularly. As application areas of CRISPR are …