Neuropeptide Y (NPY) is one the most potent orexigenic peptides found in the brain. It
stimulates food intake with a preferential effect on carbohydrate intake. It decreases latency …

A obesidade já é considerada uma epidemia mundial independente de condições
econômicas e sociais. O risco aumentado de mortalidade e morbidade associado à …

Obesity alters adipose tissue metabolic and endocrine function and leads to an increased
release of fatty acids, hormones, and proinflammatory molecules that contribute to obesity …

The immune-modulating cytokine interleukin-6 (IL-6) is expressed both in adipose tissue
and centrally in hypothalamic nuclei that regulate body composition. We investigated the …

Knockout (KO) mice lacking steroidogenic factor 1 (SF-1) exhibit a phenotype that includes
adrenal and gonadal agenesis, impaired gonadotropin expression, and abnormalities of the …

The functional loss of both alleles of the human pro-opiomelanocortin (POMC) gene leads to
a very rare syndrome of hypoadrenalism, red hair and early-onset obesity. In order to …

This is the ninth update of the human obesity gene map, incorporating published results
through October 2002 and continuing the previous format. Evidence from single‐gene …

We recently identified mutations in the lipin gene, Lpin1, as the cause of lipodystrophy in the
fatty liver dystrophy (fld) mouse. Here we identify impaired adipocyte differentiation as the …

Fasting hyperglycemia in patients with type 2 diabetes mellitus (T2DM) is attributed to
increased hepatic gluconeogenesis, which has been ascribed to increased transcriptional …

Histamine H1 receptors (H1-Rs) are found in peripheral tissues and in regions of the
hypothalamus that are concerned with regulating body composition. In the present study, we …