Ferroptosis-a new target of osteoporosis

Z Gao, Z Chen, Z Xiong, X Liu - Experimental gerontology, 2022 - Elsevier
Osteoporosis is a bone metabolic disease characterized by reduced bone mass and
deterioration of bone tissue microarchitecture, leading to enhanced skeletal fragility and …

[HTML][HTML] Exploration of the molecular mechanism of polygonati rhizoma in the treatment of osteoporosis based on network pharmacology and molecular docking

J Zhao, F Lin, G Liang, Y Han, N Xu, J Pan… - Frontiers in …, 2022 - frontiersin.org
Objective To explore the effective components and mechanism of Polygonati Rhizoma (PR)
in the treatment of osteoporosis (OP) based on network pharmacology and molecular …

Circulating MicroRNAs as biomarkers of osteoporosis and fragility fractures

S Ciuffi, F Marini, C Fossi, S Donati… - The Journal of …, 2022 - academic.oup.com
Context Measurement of circulating microRNAs (miRNAs) as potential biomarkers of fragility
fracture risk has recently become a subject of investigation. Objective Measure by next …

[HTML][HTML] Methyltransferase Setdb1 promotes osteoblast proliferation by epigenetically silencing Macrod2 with the assistance of Atf7ip

L Zhang, L Xu, X Zhang, K Wang, Y Tan, G Li, Y Wang… - Cells, 2022 - mdpi.com
Bone loss caused by mechanical unloading is a threat to prolonged space flight and human
health. Epigenetic modifications play a crucial role in varied biological processes, but the …

Formononetin improves the inflammatory response and bone destruction in knee joint lesions by regulating the NF‐kB and MAPK signaling pathways

K Ni, L Ye, Y Zhang, J Fang, T Yang… - Phytotherapy …, 2023 - Wiley Online Library
Formononetin (FMN) is a phytoestrogen that belongs to the isoflavone family. It has
antioxidant and anti‐inflammatory effects, as well as, many other biological activities …

Exploring epigenetic strategies for the treatment of osteoporosis

SJ Yi, J Lim, K Kim - Molecular Biology Reports, 2024 - Springer
The worldwide trend toward an aging population has resulted in a higher incidence of
chronic conditions, such as osteoporosis. Osteoporosis, a prevalent skeletal disorder …

核因子κB 受体活化因子信号转导机制与破骨细胞的活化

陈锋, 任国武, 章晓云, 陈跃平, 石儒生 - 中国组织工程研究, 2023 - cjter.com
核因子κB 受体活化因子信号转导机制与破骨细胞的活化 Page 1 Chinese Journal of Tissue
Engineering Research|Vol 27|No.2|January 2023|293 中国组织工程研究 Chinese Journal of …

LINC00370 modulates miR-222-3p-RGS4 axis to protect against osteoporosis progression

L Li, B Zheng, F Zhang, X Luo, F Li, T Xu, H Zhao… - Archives of Gerontology …, 2021 - Elsevier
Background We aimed to determine the role of the LINC00370/miR-222-3p/RGS4 axis in
modulating the process of adipose-derived stem cell (ADSC) osteogenic differentiation …

Role of epigenetic regulatory mechanisms in age‐related bone homeostasis imbalance

Y Zhong, X Zhou, Z Pan, J Zhang, J Pan - The FASEB Journal, 2024 - Wiley Online Library
Alterations to the human organism that are brought about by aging are comprehensive and
detrimental. Of these, an imbalance in bone homeostasis is a major outward manifestation of …

[HTML][HTML] 六味地黄丸减轻绝经后骨质疏松症及疲劳的作用机制: 基于抑制表观调控分子BRD4 通路

阮红良, 佘冬梅, 孙绍裘 - Journal of Southern Medical University, 2023 - ncbi.nlm.nih.gov
六味地黄丸减轻绝经后骨质疏松症及疲劳的作用机制: 基于抑制表观调控分子BRD4通路- PMC
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