The blood-brain barrier (BBB) is vital for maintaining brain homeostasis by enabling an
exquisite control of exchange of compounds between the blood and the brain parenchyma …

Parkinson's disease (PD) is a slowly progressive multisystem disorder affecting
dopaminergic neurons of the substantia nigra pars compacta (SNpc), which is characterized …

Microglia-mediated neuroinflammation and mitochondrial dysfunction play critical role in the
pathogenic process of Parkinson's disease (PD). Mitophagy plays central role in …

Citronellol, a monoterpene found in the essential oils of Cymbopogo plants has been
reported to possess various biological properties. In the present study, we investigated the …

Astrocytes play multifaceted and vital roles in maintaining neurophysiological function of the
central nervous system by regulating homeostasis, increasing synaptic plasticity, and …

Epigallocatechin 3-gallate (EGCG), an abundant polyphenolic component derived from
green tea extract, possesses versatile bioactivities that can combat many diseases. During …

Microglia, the resident immune cells of the central nervous system, mediate brain
homeostasis by controlling neuronal proliferation/differentiation and synaptic activity. In …

Inflammatory responses, including glial cell activation and peripheral immune cell infiltration,
are involved in the pathogenesis of Parkinson's disease (PD). These inflammatory …

Abstract Background Neural stem cells (NSCs) have the ability to generate a variety of
functional neural cell types and have a high potential for neuronal cell regeneration and …

There is a principle in science, known as Occam's razor, that says the correct solution is
usually the one with the simplest explanation. The microbiota-gut-brain axis, an …