Down syndrome is the most common chromosomal disorder, associated with moderate to
severe intellectual disability. While life expectancy of Down syndrome population has greatly …

Nowadays, aging is understood as a dynamic and multifaceted dysregulation process that
spares almost no human organ or cell. The immune system being among the most affected …

The thymus plays a fundamental role in establishing and maintaining central and peripheral
tolerance and defects in thymic architecture or AIRE expression result in the development of …

Down syndrome fits an immunophenotype of combined immunodeficiency with
immunodysregulation, manifesting with increased susceptibility to infections, autoimmunity …

Down syndrome (DS) patients prematurely show clinical manifestations usually associated
with aging. Their immune system declines earlier than healthy individuals, leading to …

Objective. The aim of the study was to investigate the expression patterns of a specific set of
genes involved in the inflammation process in children with Down Syndrome (DS) and …

Trisomy 21-driven transcriptional alterations in human thymus were characterized through
gene coexpression network (GCN) and miRNA-target analyses. We used whole thymic …

Down syndrome (DS) is a genetic condition caused by the triplication of chromosome 21.
Persons with DS exhibit pronounced muscle weakness, which also occurs in the Ts65Dn …

There are an estimated 6 million people with Down syndrome (DS) worldwide. In developed
countries, the vast majority of these individuals will develop Alzheimer's disease …

Down's syndrome (DS) is the most frequent genetic cause of intellectual disability and is a
chromosomal abnormality of chromosome 21 trisomy. The pericentrin gene (PCNT) has …