The central nervous system (CNS) is a complex biological system composed of numerous
cell types working in concert. The intricate development and functioning of this highly …

Holoprosencephaly (HPE) is a complex brain malformation resulting from incomplete
cleavage of the prosencephalon, occurring between the 18th and the 28th day of gestation …

Holoprosencephaly (HPE), the most common forebrain malformation, is characterized by an
incomplete separation of the cerebral hemispheres. Mutations in the homeobox gene SIX3 …

The homeobox gene superfamily encodes transcription factors that act as master regulators
of development through their ability to activate or repress a diverse range of downstream …

Background Holoprosencephaly (HPE) is the most common forebrain defect in humans. It
results from incomplete midline cleavage of the prosencephalon. Methods A large European …

Background: Holoprosencephaly (HPE) is the most common structural malformation of the
human forebrain. There are several important HPE mutational target genes, including the …

The homeotic protein SIX3 is a transcription factor vital for neurogenesis and has a bivalent
promoter. We previously showed that SIX3 can be transcriptionally silenced by DNA …

Holoprosencephaly (HPE) is a brain malformation which results from a primary defect in
induction and patterning of the rostral neural tube during early embryogenesis and usually …

The homeobox gene Six3 represses Wnt1 transcription. It is also required in the anterior
neural plate for the development of the mammalian rostral forebrain. We have now …

Holoprosencephaly is a spectrum of congenital defects of forebrain development
characterized by incomplete separation of the cerebral hemispheres. In vivo diagnosis can …