What we talk about when we talk about fat

ED Rosen, BM Spiegelman - Cell, 2014 - cell.com
There has been an upsurge of interest in the adipocyte coincident with the onset of the
obesity epidemic and the realization that adipose tissue plays a major role in the regulation …

White adipocyte dysfunction and obesity-associated pathologies in humans

CE Hagberg, KL Spalding - Nature Reviews Molecular Cell Biology, 2024 - nature.com
The prevalence of obesity and associated chronic diseases continues to increase
worldwide, negatively impacting on societies and economies. Whereas the association …

Sex-specific adipose tissue imprinting of regulatory T cells

A Vasanthakumar, D Chisanga, J Blume, R Gloury… - Nature, 2020 - nature.com
Adipose tissue is an energy store and a dynamic endocrine organ,. In particular, visceral
adipose tissue (VAT) is critical for the regulation of systemic metabolism,. Impaired VAT …

Gut microbiome may contribute to insulin resistance and systemic inflammation in obese rodents: a meta-analysis

N Jiao, SS Baker, CA Nugent… - Physiological …, 2018 - journals.physiology.org
A number of studies have associated obesity with altered gut microbiota, although results
are discordant regarding compositional changes in the gut microbiota of obese animals …

An update on physical health and economic consequences of overweight and obesity

DT Chu, NTM Nguyet, TC Dinh, NVT Lien… - Diabetes & Metabolic …, 2018 - Elsevier
Overweight and obesity (OW and OB) have been on the increase globally and posed health
risks to the world's population of all ages, including pre-born babies, children, adolescents …

The relationship between male BMI and waist circumference on semen quality: data from the LIFE study

ML Eisenberg, S Kim, Z Chen, R Sundaram… - Human …, 2014 - academic.oup.com
STUDY QUESTION What is the relationship between body size, physical activity and semen
parameters among male partners of couples attempting to become pregnant? SUMMARY …

The effect of underweight on female and male reproduction

C Boutari, PD Pappas, G Mintziori, MP Nigdelis… - Metabolism, 2020 - Elsevier
Chronic energy deficiency can impair the hypothalamic-pituitary-gonadal (HPG) axis and
lead to hypothalamic anovulation in underweight women. This review presents the …

Body weight loss reverts obesity-associated hypogonadotropic hypogonadism: a systematic review and meta-analysis

G Corona, G Rastrelli, M Monami, F Saad… - European journal of …, 2013 - academic.oup.com
Objective Few randomized clinical studies have evaluated the impact of diet and physical
activity on testosterone levels in obese men with conflicting results. Conversely, studies on …

The deep correlation between energy metabolism and reproduction: a view on the effects of nutrition for women fertility

R Fontana, S Della Torre - Nutrients, 2016 - mdpi.com
In female mammals, mechanisms have been developed, throughout evolution, to integrate
environmental, nutritional and hormonal cues in order to guarantee reproduction in …

Obesity, a serious etiologic factor for male subfertility in modern society

Y Liu, Z Ding - Reproduction, 2017 - rep.bioscientifica.com
Obesity, defined as excessive accumulation of fat in adipose tissue, is a metabolic disorder
resulting from behavioral, environmental and heritable causes. Obesity increases the risks of …