The integrin family of transmembrane adhesion receptors coordinates complex signaling
networks that control the ability of cells to sense and communicate with the extracellular …

Abstract Kindlins are 4.1-ezrin-ridixin-moesin (FERM) domain containing proteins. There are
three kindlins in mammals, which share high sequence identity. Kindlin-1 is expressed …

Kindlins are essential for integrin activation in cell systems and do so by working in a
cooperative fashion with talin via their direct interaction with integrin β cytoplasmic tails …

Integrins are heterodimeric receptors comprising α and β subunits. They are expressed on
the cell surface and play key roles in cell adhesion, migration, and growth. Several types of …

It has been well established that integrins mediate cell–cell and cell–matrix adhesion and
play crucial roles in the immune system such as leukocyte–endothelium interactions …

Osteopetrosis is a genetic condition of the skeleton characterized by increased bone density
caused by osteoclast formation and function defects. Osteopetrosis is inherited in the form of …

Following injury to the blood vessel, platelets adhere to exposed subendothelium by a
process (adhesion) that involves, among other events, the interaction of a plasma protein …

The protein kindlin 3 is mutated in the leukocyte adhesion deficiency III (LAD-III) disorder,
leading to widespread infection due to the failure of leukocytes to migrate into infected tissue …

Simple Summary Studies from our group and others have established Kindlin-2 that is
expressed in the cancer cells as a major driver of tumor progression and metastasis in …

Upon vascular injury, platelets adhere to the exposed extracellular matrix, which triggers the
platelet activation and aggregation to form a hemostatic plug to seal the wound. All of these …