Integrins are cell surface adhesion and signaling receptors important for cell adhesion,
survival and migration. Integrins are known to be regulated by signals from inside the cells …

Leukocyte adhesion deficiency (LAD) is an immunodeficiency caused by defects in the
adhesion of leukocytes (especially neutrophils) to the blood vessel wall. As a result, patients …

The ability of small blood vessels to undergo rapid, reversible morphological changes is
essential for the adaptive response to tissue injury or local infection. A canonical feature of …

CLEC-2 is a C-type lectin receptor which is highly expressed on platelets but also found at
low levels on different immune cells. CLEC-2 elicits powerful platelet activation upon …

Lessons from rare maladies: leukocyte adhesion deficiency sy... : Current Opinion in
Hematology Lessons from rare maladies: leukocyte adhesion deficiency syndromes …

Kindlins are a subclass of FERM-containing proteins that have recently emerged as key
regulators of integrin receptor activation and signaling. As compared with the conventional …

Chemokine signals activate leukocyte integrins and actin remodeling machineries critical for
leukocyte adhesion and motility across vascular barriers. The arrest of leukocytes at target …

Defects in platelet function or formation increase the risk for bleeding or thrombosis, which
indicates the crucial role for platelets in maintaining haemostasis in normal life. Upon …

The Kindlin family of intracellular proteins has recently emerged as key regulators of cellular
functions and cell-matrix interactions. The 3 members of this family, Kindlin-1,-2, and-3 …

A close homologue to protein disulfide isomerase (PDI) called ERp57 forms disulfide bonds
in glycoproteins in the endoplasmic reticulum and is expressed on the platelet surface. We …