How platelet activation begins, and the degree to which it is essential, depends in part on
where it occurs within the circulation and why. In the venous system, low flow rates and …

β2 integrins are expressed on all leukocytes. Precise regulation of the β2 integrin is critical
for leukocyte adhesion and trafficking. In neutrophils, β2 integrins participate in slow rolling …

Integrin activation is a predominant step for cell–cell and cell–ECM interactions. Talin and
Kindlin are mechanosensitive adaptor proteins that bind to the integrin cytoplasmic tail and …

The FERM domain containing protein Kindlin-3 has been recognized as a major regulator of
integrin function in hematopoietic cells, but its role in neoplasia is totally unknown. We have …

The kindlins represent a class of focal adhesion proteins implicated in integrin activation.
They comprise three evolutionarily conserved members, kindlin-1, kindlin-2 and kindlin-3 …

Cell adhesion and migration depend on engagement of extracellular matrix ligands by
integrins. Integrin activation is dynamically regulated by interactions of various cytoplasmic …

The role of integrins in angiogenesis has been demonstrated to include, in addition to cell
adhesion and mechanotransduction, specific signaling functions. The importance of integrin …

Kindlin-2, a widely distributed cytoskeletal protein, has been implicated in integrin activation,
and its absence is embryonically lethal in mice and causes severe developmental defects in …

The actin cytoskeleton has been reported to restrict signalling in resting immune cells. Beta2-
integrins, which mediate adhesion and cytoskeletal organization, are emerging as negative …

ADAP is a hematopoietic-restricted adapter protein that promotes integrin activation and is a
carrier for other adapter proteins, Src kinase–associated phosphoprotein 1 (SKAP1) and …