Inflammasomes are large protein complexes that play a major role in sensing inflammatory
signals and triggering the innate immune response. Each inflammasome complex has three …

Pyroptosis is a programmed cell death mode discovered in recent years. It is caused by
inflammasomes and the perforation of Gasdermin family proteins, and results in the release …

Cadmium (Cd) is a widespread environmental and industrial pollutant to cause various bone
metabolic diseases. Our former study reported that Cd promoted adipogenesis and inhibited …

Exploring the immune mechanism of coxsackievirus B3 (CVB3)-induced myocarditis may
provide a promising therapeutic strategy. Here, we investigated the regulatory role of …

During myocardial ischemia and reperfusion (IR) injury matrix metalloproteinase-2 (MMP-2)
is rapidly activated in response to oxidative stress. MMP-2 is a multifunctional protease that …

Dilated cardiomyopathy (DCM) is a leading cause of heart failure and the most common
indication for heart transplantation. Currently, there is still an unmet clinical need in effective …

In addition to housing the major energy-producing pathways in cells, mitochondria are active
players in innate immune responses. One critical way mitochondria fulfill this role is by …

Periprosthetic osteolysis (PPO) along with aseptic loosening (AL) caused by wear particles
after artificial joint replacement is the key factor in surgical failure and subsequent revision …

Background Intervertebral disc degeneration (IDD) is one of the most common health
problems in the elderly and a major causative factor in low back pain (LBP). An increasing …

Pyroptosis plays an important role in inflammatory diseases such as viral hepatitis and
atherosclerosis. Apigenin exhibits various bioactivities, particularly anti‐inflammation, but its …