Mechanisms of nanoparticle transport across intestinal tissue: an oral delivery perspective

SA Ejazi, R Louisthelmy, K Maisel - ACS nano, 2023 - ACS Publications
Oral drug administration has been a popular choice due to patient compliance and limited
clinical resources. Orally delivered drugs must circumvent the harsh gastrointestinal (GI) …

Progress and prospects of polysaccharide-based nanocarriers for oral delivery of proteins/peptides

H Yuan, C Guo, L Liu, L Zhao, Y Zhang, T Yin… - Carbohydrate …, 2023 - Elsevier
The oral route has long been recognized as the most preferred route for drug delivery as it
offers high patient compliance and requires minimal expertise. Unlike small molecule drugs …

Chiral nanosilica drug delivery systems stereoselectively interacted with the intestinal mucosa to improve the oral adsorption of insoluble drugs

X Chen, Y Cheng, Q Pan, L Wu, X Hao, Z Bao, X Li… - ACS …, 2023 - ACS Publications
Chiral nanoparticles (NPs) with nanoscale rough surfaces have enormous application
prospects in drug delivery. However, the stereoselective interactions between the chiral NPs …

[HTML][HTML] Development of an orally delivered GLP-1 receptor agonist through peptide engineering and drug delivery to treat chronic disease

S Pechenov, J Revell, S Will, J Naylor, P Tyagi… - Scientific reports, 2021 - nature.com
Peptide therapeutics are increasingly used in the treatment of disease, but their
administration by injection reduces patient compliance and convenience, especially for …

Interactions between nanoparticles and lymphatic systems: Mechanisms and applications in drug delivery

Y Tang, B Liu, Y Zhang, Y Liu, Y Huang… - Advanced Drug Delivery …, 2024 - Elsevier
The lymphatic system has garnered significant attention in drug delivery research due to the
advantages it offers, such as enhancing systemic exposure and enabling lymph node …

[HTML][HTML] Transporter-mediated drug delivery

G Gyimesi, MA Hediger - Molecules, 2023 - mdpi.com
Transmembrane transport of small organic and inorganic molecules is one of the
cornerstones of cellular metabolism. Among transmembrane transporters, solute carrier …

Nanocarriers transport across the gastrointestinal barriers: the contribution to oral bioavailability via blood circulation and lymphatic pathway

D Wang, Q Jiang, Z Dong, T Meng, F Hu, J Wang… - Advanced Drug Delivery …, 2023 - Elsevier
Oral administration is the preferred route of drug delivery in clinical practice due to its
noninvasiveness, safety, convenience, and high patient compliance. The gastrointestinal …

[HTML][HTML] Recent developments and applications of smart nanoparticles in biomedicine

S Campora, G Ghersi - Nanotechnology Reviews, 2022 - degruyter.com
Over the last decades, nanotechnology applied in medicine (nanomedicine) has sparked
great interest from the scientific community, thanks to the possibility to engineer …

[HTML][HTML] Development and pharmacokinetic evaluation of a self-nanoemulsifying drug delivery system for the oral delivery of cannabidiol

LY Kok, P Bannigan, F Sanaee, JC Evans… - European Journal of …, 2022 - Elsevier
The number of lipophilic drug candidates in pharmaceutical discovery pipelines has
increased in recent years. These drugs often possess physicochemical properties that result …

[HTML][HTML] Current research trends of nanomedicines

Q Liu, J Zou, Z Chen, W He, W Wu - Acta Pharmaceutica Sinica B, 2023 - Elsevier
Owing to the inherent shortcomings of traditional therapeutic drugs in terms of inadequate
therapeutic efficacy and toxicity in clinical treatment, nanomedicine designs have received …