Unveiling the role of nonionic surfactants in enhancing cefotaxime drug solubility: a UV-Visible spectroscopic investigation in single and mixed micellar formulations

AA Rana, A Yusaf, S Shahid, M Usman, M Ahmad… - Pharmaceuticals, 2023 - mdpi.com
This study reports the interfacial phenomenon of cefotaxime in combination with nonionic
surfactants, Triton X-100 (TX-100) and Tween-80 (TW-80), and their mixed micellar …

Oral Multidrug CoDelivery System Targeting Differential Sites for Diabetes Mellitus Treatment

H Zhang, R Wang, Z Xu, S Deng… - Advanced Functional …, 2024 - Wiley Online Library
Although regulation of the blood glucose level is a common therapy for Type 2 diabetes
mellitus (T2DM), the root cause of this disease (such as the damage of pancreatic β cells) …

[HTML][HTML] Vegetable oils composition affects the intestinal lymphatic transport and systemic bioavailability of co-administered lipophilic drug cannabidiol

W Feng, C Qin, S Abdelrazig, Z Bai, M Raji… - International journal of …, 2022 - Elsevier
Although natural sesame oil has been shown to facilitate the lymphatic delivery and oral
bioavailability of the highly lipophilic drug cannabidiol (CBD), considerable variability …

The emerging roles of long noncoding RNAs in lymphatic vascular development and disease

KI Ivanov, OV Samuilova, AA Zamyatnin Jr - Cellular and Molecular Life …, 2023 - Springer
Recent advances in RNA sequencing technologies helped uncover what was once
uncharted territory in the human genome—the complex and versatile world of long …

Developments and challenges for new and emergent preparations for male hypogonadism treatment

G Corona, C Sparano, G Rastrelli… - Expert Opinion on …, 2023 - Taylor & Francis
Introduction The specific role of testosterone (T) replacement therapy in patients with late
onset hypogonadism is still conflicting. Several available preparations have been developed …

Quality by design (QbD) commended exploration of bosutinib loaded lipid nanocarriers for food effect attenuation and bioavailability enhancement in breast cancer

P Famta, S Shah, G Vambhurkar… - Journal of Drug Delivery …, 2023 - Elsevier
Bosutinib (BOS), a BCS class IV drug suffers from poor aqueous solubility and bioavailability
along with significant food effect. Lipid nanocarriers (LNC) have the potential to circumvent …

The role of nanocarriers for transdermal application targeted to lymphatic drug delivery: Opportunities and challenges

TC De Oliveira, MEV Tavares… - Journal of Drug Delivery …, 2022 - Elsevier
The transdermal route is a promising drug delivery strategy as it is a non-invasive pathway. It
may provide a controlled drug release, with longer-lasting effects on the organism as it does …

Recent advances in oral peptide or protein-based drug liposomes

J Cui, Z Wen, W Zhang, W Wu - Pharmaceuticals, 2022 - mdpi.com
The high physiology and low toxicity of therapeutic peptides and proteins have made them a
hot spot for drug development in recent years. However, their poor oral bioavailability and …

[HTML][HTML] Development and in vivo pharmacokinetic and pharmacodynamic evaluation of an oral innovative cyclodextrin complexed lipid nanoparticles of irbesartan …

N Dudhipala, S Ettireddy, AAA Youssef… - …, 2023 - ncbi.nlm.nih.gov
Background: Irbesartan (IR) is used in the treatment of hypertension, heart failure, and
nephropathy in Type II diabetes. IR bioavailability is limited by poor solubility and …

The lymphatic system: A sometimes-forgotten compartment in pharmaceutical sciences

M Yousef, D Silva, NB Chacra… - … of Pharmacy & …, 2021 - journals.library.ualberta.ca
The uniqueness of structure and physiology of the lymphatic system make it challenging to
delineate all its contributions in the maintenance of our health. However, in the past two …