SRS-FISH: A high-throughput platform linking microbiome metabolism to identity at the single-cell level

X Ge, FC Pereira, M Mitteregger… - Proceedings of the …, 2022 - National Acad Sciences
One of the biggest challenges in microbiome research in environmental and medical
samples is to better understand functional properties of microbial community members at a …

Tumor Microenvironment-Responsive Yolk–Shell NaCl@Virus-Inspired Tetrasulfide-Organosilica for Ion-Interference Therapy via Osmolarity Surge and Oxidative …

Y Li, J Lin, P Wang, F Zhu, M Wu, Q Luo, Y Zhang… - ACS …, 2022 - ACS Publications
Ion-interference therapy, which utilizes ions to disturb intracellular biological processes,
provides inspiration for tumor therapy. Artificially reversing osmotic pressure by transporting …

Pinpointing Fat Molecules: Advances in Coherent Raman Scattering Microscopy for Lipid Metabolism

X Huang, Z Xue, D Zhang, HJ Lee - Analytical Chemistry, 2024 - ACS Publications
At the heart of numerous diseases, lipids are a diverse array of chemically and functionally
heterogeneous compounds found in organisms. Their significance as energy sources …

[HTML][HTML] Bond-selective intensity diffraction tomography

J Zhao, A Matlock, H Zhu, Z Song, J Zhu… - Nature …, 2022 - nature.com
Recovering molecular information remains a grand challenge in the widely used
holographic and computational imaging technologies. To address this challenge, we …

Stimulated Raman photothermal microscopy toward ultrasensitive chemical imaging

Y Zhu, X Ge, H Ni, J Yin, H Lin, L Wang, Y Tan… - Science …, 2023 - science.org
Stimulated Raman scattering (SRS) microscopy has shown enormous potential in revealing
molecular structures, dynamics, and couplings in complex systems. However, the sensitivity …

Fingerprint Stimulated Raman Scattering Imaging Unveils Ergosteryl Ester as a Metabolic Signature of Azole-Resistant Candida albicans

M Zhang, PT Dong, HE Eldesouky, Y Zhan… - Analytical …, 2023 - ACS Publications
Candida albicans (C. albicans), a major fungal pathogen, causes life-threatening infections
in immunocompromised individuals. Fluconazole (FLC) is recommended as first-line therapy …

[HTML][HTML] Targeted delivery of organic small-molecule photothermal materials with engineered extracellular vesicles for imaging-guided tumor photothermal therapy

Y Dong, P Xia, X Xu, J Shen, Y Ding, Y Jiang… - Journal of …, 2023 - Springer
Imaging-guided photothermal therapy (PTT) for cancers recently gathered increasing focus
thanks to its precise diagnosis and potent therapeutic effectiveness. Croconaine (CR) dyes …

Metabolic pathway of monounsaturated lipids revealed by in-depth structural Lipidomics by mass spectrometry

S Cheng, D Zhang, J Feng, Q Hu, A Tan, Z Xie, Q Chen… - Research, 2023 - spj.science.org
The study of lipid metabolism relies on the characterization of the lipidome, which is quite
complex due to the structure variations of the lipid species. New analytical tools have been …

Label-Free Raman Spectromicroscopy Unravels the Relationship between MGMT Methylation and Intracellular Lipid Accumulation in Glioblastoma

N Wang, J Wang, P Wang, N Ji, S Yue - Analytical Chemistry, 2023 - ACS Publications
Temozolomide (TMZ) is considered a first line chemotherapy drug for glioblastoma (GBM).
Unfortunately, the GBM without methylation of O6-methylguanine-DNA methyltransferase …

Stimulated raman photothermal microscopy towards ultrasensitive chemical imaging

Y Zhu, X Ge, H Ni, J Yin, H Lin, L Wang, Y Tan… - bioRxiv, 2023 - biorxiv.org
Stimulated Raman scattering (SRS) microscopy has shown enormous potential in revealing
molecular structures, dynamics and coupling in a complex system–. However, the bond …