The ultimate goal of any treatment for autoimmune diseases is antigen-and/or site-specific
suppression of pathology. Autoaggressive lymphocytes need to be eliminated or controlled …

With studies elucidating the cytokine programs associated with T-cell activation, allograft
rejection and tolerance induction, the Thl/Th2 paradigm has become a unifying model to …

Specific and selective immunological unresponsiveness to donor alloantigens can be
induced in vivo. We have shown previously that CD25+ CD4+ T cells from mice exhibiting …

The maintenance of transplantation tolerance induced in adult mice after short-term
treatment with nonlytic monoclonal antibodies to CD4 and CD8 was investigated. CD4+ T …

Induction of transplantation tolerance with certain therapeutic nondepleting monoclonal
antibodies can lead to a robust state of peripheral “dominant” tolerance. Regulatory CD4+ T …

Transplantation tolerance can be induced in mice by grafting under the cover of
nondepleting CD4 plus CD8 or CD154 mAbs. This tolerance is donor Ag specific and …

There are three possible outcomes when a T cell recognizes a cell bearing a self or foreign
antigen.(i) The T cell is not sufficiently signaled and is unaffected.(ii) The T cell is …

Susceptibility to neuroinflammatory disease is influenced in part by genetics. Recent data
indicate that survival of traumatized neurons is strain dependent and influenced by …

Abstract CD4+ CD25+ T cells have been proposed as the principal regulators of both self-
tolerance and transplantation tolerance. Although CD4+ CD25+ T cells do have a …

A paradigm shift in immunology has been the recent discovery of regulatory T cells (T reg
cells), of which CD4+ Foxp3+ cells are proven as essential to self-tolerance. Using …