Neuroinflammation in Alzheimer's disease

IG Onyango, GV Jauregui, M Čarná, JP Bennett Jr… - Biomedicines, 2021 - mdpi.com
Alzheimer's disease (AD) is a neurodegenerative disease associated with human aging.
Ten percent of individuals over 65 years have AD and its prevalence continues to rise with …

Involvement of astrocytes in Alzheimer's disease from a neuroinflammatory and oxidative stress perspective

RE González-Reyes, MO Nava-Mesa… - Frontiers in molecular …, 2017 - frontiersin.org
Alzheimer disease (AD) is a frequent and devastating neurodegenerative disease in
humans, but still no curative treatment has been developed. Although many explicative …

[HTML][HTML] Cytokines and chemokines: At the crossroads of cell signalling and inflammatory disease

MD Turner, B Nedjai, T Hurst, DJ Pennington - Biochimica et Biophysica …, 2014 - Elsevier
Inflammation occurs as a result of exposure of tissues and organs to harmful stimuli such as
microbial pathogens, irritants, or toxic cellular components. The primary physical …

Neurodegeneration and neuro-regeneration—Alzheimer's disease and stem cell therapy

V Vasic, K Barth, MHH Schmidt - International journal of molecular …, 2019 - mdpi.com
Aging causes many changes in the human body, and is a high risk for various diseases.
Dementia, a common age-related disease, is a clinical disorder triggered by …

Dysfunctional synapse in Alzheimer's disease–A focus on NMDA receptors

SI Mota, IL Ferreira, AC Rego - Neuropharmacology, 2014 - Elsevier
Alzheimer's disease (AD) is the most prevalent form of dementia in the elderly. Alterations
capable of causing brain circuitry dysfunctions in AD may take several years to develop …

An emerging role of astrocytes in aging/neuroinflammation and gut-brain axis with consequences on sleep and sleep disorders

SV Gudkov, DE Burmistrov, EV Kondakova… - Ageing Research …, 2023 - Elsevier
Understanding the role of astrocytes in the central nervous system has changed dramatically
over the last decade. The accumulating findings indicate that glial cells are involved not only …

Alzheimer's disease: An overview of amyloid beta dependent pathogenesis and its therapeutic implications along with in silico approaches emphasizing the role of …

M Awasthi, S Singh, VP Pandey, UN Dwivedi - Journal of the neurological …, 2016 - Elsevier
Alzheimer's disease (AD) is a progressive and irreversible neurodegenerative disorder
characterized by amyloid beta (Aβ) deposition in brain with subsequent formation of neuritic …

APOE‐modulated Aβ‐induced neuroinflammation in Alzheimer's disease: current landscape, novel data, and future perspective

LM Tai, S Ghura, KP Koster, V Liakaite… - Journal of …, 2015 - Wiley Online Library
Chronic glial activation and neuroinflammation induced by the amyloid‐β peptide (Aβ)
contribute to Alzheimer's disease (AD) pathology. APOE 4 is the greatest AD‐genetic risk …

Clearance of amyloid-β peptides by microglia and macrophages: the issue of what, when and where

AY Lai, JA McLaurin - Future neurology, 2012 - Taylor & Francis
Accumulation of senile plaques consisting of amyloid-β peptide (Aβ) aggregates is a
prominent pathological feature in Alzheimer's disease. Effective clearance of Aβ from the …

GABAergic neurotransmission and new strategies of neuromodulation to compensate synaptic dysfunction in early stages of Alzheimer's disease

MO Nava-Mesa, L Jiménez-Díaz, J Yajeya… - Frontiers in cellular …, 2014 - frontiersin.org
Alzheimer's disease (AD) is a progressive neurodegenerative disease characterized by
cognitive decline, brain atrophy due to neuronal and synapse loss, and formation of two …