Chagas disease is a vector-borne illness caused by the protozoan parasite Trypanosoma
cruzi (T. cruzi). It poses a significant public health burden, particularly in the poorest regions …

Natural extracts have been and continue to be used to treat a wide range of medical
conditions, from infectious diseases to cancer, based on their convenience and therapeutic …

Chagas disease still has no effective treatment option for all of its phases despite being
discovered more than 100 years ago. The development of commercial drugs has been …

Chagas disease (CD) is a worldwide problem, with over 8 million people infected in both
rural and urban areas. CD was first described over a century ago, but only two drugs are …

Leishmaniasis (Leishmania species), sleeping sickness (Trypanosoma brucei), and Chagas
disease (Trypanosoma cruzi) are devastating and globally spread diseases caused by …

Metalloenzymes are central to the regulation of a wide range of essential viral and parasitic
functions, including protein degradation, nucleic acid modification, and many others. Given …

Introduction American trypanosomiasis, better known as Chagas disease, is a global public
health issue. Current treatments targeting the causative parasite, Trypanosoma cruzi, are …

Background: Chagas disease (American Trypanosomiasis) is classified by the World Health
Organization (WHO) as one of the seventeen neglected tropical diseases (NTD), affecting …

Chagas disease is one of the most prevalent tropical neglected diseases and causes high
mortality and morbidity in endemic countries. Current treatments for this disease, nifurtimox …

The present systematic review and meta-analysis about the accuracy of diagnostic tests aim
to describe the findings of literature over the last thirty years for the diagnosis of Chagas …