Design, Synthesis, Nematicidal Activity, and Mechanism of Novel Amide Derivatives Containing an 1, 2, 4-Oxadiazole Moiety

Y Wang, H Song, S Wang, Q Cai… - Journal of Agricultural and …, 2023 - ACS Publications
To discover new nematicides, a series of novel amide derivatives containing 1, 2, 4-
oxadiazole were designed and synthesized. Several compounds showed excellent …

1, 2, 4-Oxadiazole as a potential scaffold in agrochemistry: a review

Z Ju, C Wu, M Li, J Wu, Y Chen, CX Tan - Organic & Biomolecular …, 2023 - pubs.rsc.org
N, O-Containing heterocycles are incorporated in various approved pesticides and pesticide
candidates. The persistent challenge in modern crop protection is the continuous pursuit of …

Design, synthesis, and biological activity of novel chalcone derivatives containing an 1, 2, 4-oxadiazole moiety

L Luo, D Liu, S Lan, X Gan - Frontiers in Chemistry, 2022 - frontiersin.org
To discover a lead compound for agricultural use, 34 novel chalcone derivatives containing
an 1, 2, 4-oxadiazole moiety were designed and synthesized. Their nematocidal activities …

Benzamides substituted with quinoline-linked 1, 2, 4-oxadiazole: Synthesis, biological activity and toxicity to zebrafish embryo

BL Sun, YY Wang, S Yang, MT Tu, YY Shao, Y Hua… - Molecules, 2022 - mdpi.com
To develop new compounds with high activity, broad spectrum and low-toxicity, 17
benzamides substituted with quinoline-linked 1, 2, 4-oxadiazole were designed using the …

Discovery of 1, 2, 4-oxadiazole derivatives containing haloalkyl as potential acetylcholine receptor nematicides

L Luo, Y Ou, Q Zhang, X Gan - International Journal of Molecular …, 2023 - mdpi.com
Plant-parasitic nematodes pose a serious threat to crops and cause substantial financial
losses due to control difficulties. Tioxazafen (3-phenyl-5-thiophen-2-yl-1, 2, 4-oxadiazole) is …

Design, synthesis, and bioactivity of novel quinazolinone scaffolds containing pyrazole carbamide derivatives as antifungal agents

Z Lei, J Yao, H Liu, X Bai, X Gao, Q Pan… - Current Issues in …, 2022 - mdpi.com
In this study, 32 novel quinazolinone-scaffold-containing pyrazole carbamide derivatives
were designed and synthesized in a search for a novel fungicide against Rhizoctonia solani …

Structure-based Bioisosterism design, synthesis, biological activity and toxicity of 1, 2, 4-oxadiazole substituted benzamides analogues containing pyrazole rings

MT Tu, YY Shao, S Yang, BL Sun, YY Wang, CX Tan… - Molecules, 2022 - mdpi.com
In order to discover pesticidal lead compounds with high activity and low toxicity, a series of
novel benzamides substituted with pyrazole-linked 1, 2, 4-oxadiazole were designed via …

Discovery and Mechanism of a Nematicide Candidate (W3): A Novel Amide Compound Containing a Cyclopropyl Moiety

Y Wang, Y Zhang, S Wang, Q Cai… - Journal of Agricultural …, 2024 - ACS Publications
To find novel nematicides, we screened the nematicidal activity of compounds in our
laboratory compound library. Interestingly, the compound N-((1 R, 2 R)-2-(2-fluoro-4 …

Design, synthesis, antibacterial, and antifungal evaluation of novel 4-chromanone-derived compounds incorporating carboxamide and 1, 3, 4-thiadiazole thioether …

J Li, L Yu, L Xiao, M Yang, T Wu, L Zhang… - … , Sulfur, and Silicon …, 2023 - Taylor & Francis
A series of novel botanical active component 4-chromanone derivatives incorporating
carboxamide and 1, 3, 4-thiadiazole thioether moieties were synthesized and evaluated for …

Design, synthesis and antifungal activity of novel 1, 4-pentadiene-3-one containing quinazolinone

R Zhou, W Zhan, C Yuan, T Zhang, P Mao… - International Journal of …, 2023 - mdpi.com
Twenty 1, 4-pentadiene-3-one derivatives containing quinazolinone (W1–W20) were
designed and synthesized. The bioactivity test results showed that some compounds had …