Asymmetric organocatalysis: an enabling technology for medicinal chemistry

B Han, XH He, YQ Liu, G He, C Peng… - Chemical Society Reviews, 2021 - pubs.rsc.org
The efficacy and synthetic versatility of asymmetric organocatalysis have contributed
enormously to the field of organic synthesis since the early 2000s. As asymmetric …

Organocatalytic asymmetric synthesis of indole-based chiral heterocycles: strategies, reactions, and outreach

YC Zhang, F Jiang, F Shi - Accounts of chemical research, 2019 - ACS Publications
Conspectus Indole-based chiral heterocycles constitute a class of important heterocyclic
compounds that are found in numerous pharmaceuticals, functional materials, and chiral …

Progresses in organocatalytic asymmetric dearomatization reactions of indole derivatives

FT Sheng, JY Wang, W Tan, YC Zhang… - Organic Chemistry …, 2020 - pubs.rsc.org
Chiral indole derivatives such as indolines and indolenines are important heterocyclic
frameworks which constitute the core structures of many natural products and bioactive …

The hitchhiker's guide to flow chemistry∥

MB Plutschack, B Pieber, K Gilmore… - Chemical …, 2017 - ACS Publications
Flow chemistry involves the use of channels or tubing to conduct a reaction in a continuous
stream rather than in a flask. Flow equipment provides chemists with unique control over …

Organocatalysis in inert C–H bond functionalization

Y Qin, L Zhu, S Luo - Chemical reviews, 2017 - ACS Publications
As two coexisting and fast-growing research fields in modern synthetic chemistry, the
merging of organocatalysis and C–H bond functionalization is well foreseeable, and the joint …

50th Anniversary Perspective: Living PolymerizationEmphasizing the Molecule in Macromolecules

RB Grubbs, RH Grubbs - Macromolecules, 2017 - ACS Publications
The ideal of living polymerization has defined research in polymer chemistry over the past
50 years. In this Perspective, we present the case that this concept has enabled the …

Continuous flow asymmetric synthesis of chiral active pharmaceutical ingredients and their advanced intermediates

SB Ötvös, CO Kappe - Green Chemistry, 2021 - pubs.rsc.org
Catalytic enantioselective transformations provide well-established and direct access to
stereogenic synthons that are broadly distributed among active pharmaceutical ingredients …

Carbon dots as nano-organocatalysts for synthetic applications

C Rosso, G Filippini, M Prato - ACS Catalysis, 2020 - ACS Publications
Over the last decades, organic chemistry has taken a resolute step toward green catalytic
synthesis. This tries to ensure efficient and sustainable base chemical production, while also …

Chiral hypervalent iodines: active players in asymmetric synthesis

A Parra - Chemical reviews, 2019 - ACS Publications
Asymmetric organocatalytic oxidations have been witnessed to an impressive development
in the last years thanks to the establishment of important chiral hypervalent iodines (III/V) …

Advances in organocatalytic asymmetric reactions of vinylindoles: powerful access to enantioenriched indole derivatives

MS Tu, KW Chen, P Wu, YC Zhang, XQ Liu… - Organic Chemistry …, 2021 - pubs.rsc.org
Enantioenriched indole derivatives are widely found in natural products, pharmaceuticals
and bioactive compounds. Therefore, developing efficient methods for the synthesis of …