For almost 20 years, thioureas have been experiencing a renaissance of interest with the
emerged development of asymmetric organocatalysts. Due to their relatively high acidity and …

In recent years, sustainable organocatalysis has become a relevant target in asymmetric
organic synthesis. Among the most successful strategies to achieve “greener” …

A variety of spirocyclohexene pyrazolones were synthesized in good yields with excellent
stereoselectivities through an asymmetric, intermolecular, quaternary carbon center forming …

The catalytic enantioselective synthesis of the chiral key intermediate of the antidepressant
(−)-paroxetine is demonstrated as a continuous flow process on multi-gram scale. The …

Herein, an organocatalytic enantioselective desymmetrizing hydroalkoxylation of 1, 4-and 1,
8-diynes is disclosed, which represents a unique chiral Brønsted acid-catalyzed …

A novel organocatalytic activation mode of cyclopropanes is presented. The reaction
concept is based on a design in which a reactive donor–acceptor cyclopropane intermediate …

Transformation of carbon dioxide (CO 2) into value-added organic compounds is a very
important and hot research topic in green and sustainable chemistry because this …

Catalytic asymmetric Povarov protocols have undergone an explosive growth, especially in
the last ten years, since the first example was published in 1996. The use of chiral Lewis and …

The broad prospects of trifluoromethylated compounds in materials science, agricultural
chemistry, and pharmaceutical chemistry have stimulated the rapid development of …

Desymmetrization of prochiral or meso-substrates bearing pre-existing stereogenic centers
has proven to be a practical and efficient strategy in synthetic chemistry and has attracted …