The contribution of nerves to the pathogenesis of malignancies has emerged as an
important component of the tumour microenvironment. Recent studies have shown that …

Surgery is a crucial intervention and provides a chance of cure for patients with cancer. The
perioperative period is characterized by an increased risk for accelerated growth of …

Cancer recurrence after surgical resection (SR) is a considerable challenge, and the
biological effect of SR on the tumor microenvironment (TME) that is pivotal in determining …

The peripheral autonomic nervous system (ANS) is known to regulate gene expression in
primary tumours and their surrounding microenvironment. Activation of the sympathetic …

Cancer immunotherapy can confer durable benefit, but the percentage of patients who
respond to this approach remains modest. The ability to concentrate immunostimulatory …

Evidence suggests that the perioperative period and the excision of the primary tumour can
promote the development of metastases—the main cause of cancer-related mortality. This …

Purpose: Translational studies suggest that excess perioperative release of catecholamines
and prostaglandins may facilitate metastasis and reduce disease-free survival. This trial …

Background Preclinical studies have implicated excess release of catecholamines and
prostaglandins in the mediation of prometastatic processes during surgical treatment of …

The development and progression of cancer depends on both tumor micro-and
macroenvironments. In addition, psychosocial and spiritual “environments” might also affect …

Chronic stress is well-known to cause physiological distress that leads to body balance
perturbations by altering signaling pathways in the neuroendocrine and sympathetic …