Nausea, vomiting, and renal injury are the common adverse effects associated with cisplatin.
Cisplatin is excreted via the multidrug and toxin release (MATE) transporter, and the …

A survey within hematopoietic stem cell transplant (HSCT) centers of the Gruppo Italiano
Trapianto Midollo Osseo (GITMO) was performed in order to describe current antiemetic …

A concise seven‐step asymmetric synthesis of MSD's potent hNK1 antagonist containing a
pyrrolizidinone core bearing two fluorine‐substituted aryl groups was developed. The …

Atherosclerosis is the main cause of many cardiovascular diseases. Endothelial dysfunction
is recognized as an early event in the development of atherosclerosis. Many drugs have …

Context: As a bridge course between basic medicine and clinical medicine, pharmacology is
a compulsory course for students majoring in clinical medicine. Aim: The purpose this …

Rolapitant is a selective and long‐acting neurokinin‐1 receptor antagonist approved in an
oral formulation in combination with dexamethasone and a 5‐hydroxytryptamine type 3 …

Purpose Aprepitant is used to prevent nausea and vomiting associated with moderately and
highly emetogenic chemotherapy. In this open-label, 2-period study, the safety, tolerability …

OBJECTIVES: This study aimed to characterize the clinical profile and the factors that
predispose chemotherapy-induced nausea and vomiting (CINV) in the acute and delayed …

The neurokinins are indisputably essential neurotransmitters in numerous pathoand
physiological events. Being widely distributed in the Central Nervous System (CNS) and …

Chemotherapy-induced nausea and vomiting (CINV) has a severe detrimental effect on the
quality of life of patients with cancer receiving chemotherapy, and remains one of the most …