Neutrophils: important contributors to tumor progression and metastasis

A Swierczak, KA Mouchemore, JA Hamilton… - Cancer and Metastasis …, 2015 - Springer
The presence of neutrophils in tumors has traditionally been considered to be indicative of a
failed immune response against cancers. However, there is now evidence showing that …

Immune microenvironment in tumor progression: characteristics and challenges for therapy

V Chew, HC Toh, JP Abastado - Journal of oncology, 2012 - Wiley Online Library
The tumor microenvironment plays a critical role in cancer development, progression, and
control. The molecular and cellular nature of the tumor immune microenvironment influences …

Remodeled tumor immune microenvironment (TIME) parade via natural killer cells reprogramming in breast cancer

MM Elanany, DM Mostafa, NM Hamdy - Life Sciences, 2023 - Elsevier
Breast cancer (BC) is the main cause of cancer-related mortality among women globally.
Despite substantial advances in the identification and management of primary tumors …

[HTML][HTML] Ex vivo expanded natural killer cells from breast cancer patients and healthy donors are highly cytotoxic against breast cancer cell lines and patient-derived …

MM Shenouda, A Gillgrass, T Nham, R Hogg… - Breast Cancer …, 2017 - Springer
Background Natural killer (NK) cells play a critical role in cancer immunosurveillance.
Recent developments in NK cell ex-vivo expansion makes it possible to generate millions of …

The breast tumor microenvironment alters the phenotype and function of natural killer cells

T Krneta, A Gillgrass, M Chew, AA Ashkar - Cellular & molecular …, 2016 - nature.com
Natural killer (NK) cells are innate immune cells with the ability to identify and eliminate
transformed cells. However, within tumors, many studies have described NK cells as non …

Pregnancy and breast cancer

R Subramani, R Lakshmanaswamy - Progress in molecular biology and …, 2017 - Elsevier
Breast cancer is the most commonly diagnosed type of cancer among women worldwide.
The majority of breast cancers are sporadic and the etiology is not well understood. Several …

NKG2D ligand overexpression in lupus nephritis correlates with increased NK cell activity and differentiation in kidneys but not in the periphery

R Spada, JM Rojas, S Pe´ rez-Yagu¨ e… - Journal of Leucocyte …, 2015 - academic.oup.com
NK cells are a major component of the immune system, and alterations in their activity are
correlated with various autoimmune diseases. In the present work, we observed an …

Micro RNA function in NK‐cell biology

AM Beaulieu, NA Bezman, JE Lee… - Immunological …, 2013 - Wiley Online Library
The important role of micro RNA s in directing immune responses has become increasingly
clear. Here, we highlight discoveries uncovering the role of specific micro RNA s in …

Balance between activating NKG 2D, DNAM‐1, NK p44 and NK p46 and inhibitory CD 94/NKG 2A receptors determine natural killer degranulation towards …

N Nielsen, V Pascal, AER Fasth, Y Sundström… - …, 2014 - Wiley Online Library
Rheumatoid arthritis (RA) is an autoimmune disease characterized by chronic inflammation
and synovial hyperplasia leading to progressive joint destruction. Fibroblast‐like …

Long-chain polyunsaturated omega-3 fatty acids reduce multiple myeloma exosome-mediated suppression of NK cell cytotoxicity

M Moloudizargari, F Redegeld, MH Asghari… - DARU Journal of …, 2020 - Springer
Background Despite the advances in the treatment of multiple myeloma (MM), complete
remission is usually challenging. The interactions between tumor and host cells, in which …