This is the introductory paper in a series of eight papers. In this series, we integrate the
theoretical design options with the practice of conducting pragmatic trials. For most new …

Abstract Background and Objective Randomized trials may be designed to provide evidence
more strongly related to efficacy or effectiveness of an intervention. When systematic reviews …

There has been a recent surge of eHealth programs in cancer and other content areas, but
few reviews have focused on the methodologies and designs employed in these studies. We …

Background The need for high-quality evidence that is applicable in real-world, routine
settings continues to increase. Pragmatic trials are designed to evaluate the effectiveness of …

Background If you want to know which of two or more healthcare interventions is most
effective, the randomised controlled trial is the design of choice. Randomisation, however …

Background Treatment for opioid use disorder (OUD) is highly effective, yet it remains
dramatically underutilized. Individuals with OUD have disproportionately high rates of …

The US Preventive Services Task Force (USPSTF) makes recommendations on which
preventive services to routinely incorporate into primary care for specific populations …

This study reports the results of a pragmatic effectiveness–implementation hybrid trial of the
Family Check-Up (FCU) conducted in three community mental health agencies with 40 …

Objective To compare two approaches for trial teams to apply PRECIS-2 to pragmatic trials:
independent scoring and scoring following a group discussion. Study Design and Setting …

Objectives The objective of this study was to examine the impact of study characteristics on
the score of the pragmatism/explanatory continuum of randomized controlled trials (RCTs) …