Current status of the diagnosis and management of osteoporosis

A Aibar-Almazán, A Voltes-Martínez… - International journal of …, 2022 - mdpi.com
Osteoporosis has been defined as the silent disease of the 21st century, becoming a public
health risk due to its severity, chronicity and progression and affecting mainly …

Molecular mechanisms and emerging therapeutics for osteoporosis

JY Noh, Y Yang, H Jung - International journal of molecular sciences, 2020 - mdpi.com
Osteoporosis is the most common chronic metabolic bone disease. It has been estimated
that more than 10 million people in the United States and 200 million men and women …

The shift in the balance between osteoblastogenesis and adipogenesis of mesenchymal stem cells mediated by glucocorticoid receptor

L Han, B Wang, R Wang, S Gong, G Chen… - Stem cell research & …, 2019 - Springer
Mesenchymal stem cells (MSCs) are multipotent cells capable of differentiating into several
tissues, such as bone, cartilage, and fat. Glucocorticoids affect a variety of biological …

The potential use of mesenchymal stem cells and their derived exosomes for orthopedic diseases treatment

K Malekpour, A Hazrati, M Zahar, A Markov… - Stem cell reviews and …, 2022 - Springer
Musculoskeletal disorders (MSDs) are conditions that can affect muscles, bones, and joints.
These disorders are very painful and severely limit patients' mobility and are more common …

[HTML][HTML] Regional specialization and fate specification of bone stromal cells in skeletal development

KK Sivaraj, HW Jeong, B Dharmalingam, D Zeuschner… - Cell Reports, 2021 - cell.com
Bone stroma contributes to the regulation of osteogenesis and hematopoiesis but also to
fracture healing and disease processes. Mesenchymal stromal cells from bone (BMSCs) …

m6A methylation of precursor-miR-320/RUNX2 controls osteogenic potential of bone marrow-derived mesenchymal stem cells

G Yan, YE Yuan, M He, R Gong, H Lei, H Zhou… - … Therapy-Nucleic Acids, 2020 - cell.com
Methyltransferase-like 3 (METTL3) is the main enzyme for N 6-methyladenosine (m 6 A)-
based methylation of RNAs and it has been implicated in many biological and …

Cell-based therapy in thin endometrium and Asherman syndrome

N Gharibeh, L Aghebati-Maleki, J Madani… - Stem Cell Research & …, 2022 - Springer
Numerous treatment strategies have so far been proposed for treating refractory thin
endometrium either without or with the Asherman syndrome. Inconsistency in the …

Molecular-based treatment strategies for osteoporosis: a literature review

Y Ukon, T Makino, J Kodama, H Tsukazaki… - International journal of …, 2019 - mdpi.com
Osteoporosis is an unavoidable public health problem in an aging or aged society. Anti-
resorptive agents (calcitonin, estrogen, and selective estrogen-receptor modulators …

[HTML][HTML] Enhanced osseointegration of three-dimensional supramolecular bioactive interface through osteoporotic microenvironment regulation

H Bai, Y Zhao, C Wang, Z Wang, J Wang, H Liu… - Theranostics, 2020 - ncbi.nlm.nih.gov
Purpose: Osteoporosis is more likely to cause serious complications after joint replacement,
mainly due to physiological defects of endogenous osteogenic cells and the pathological …

New frontiers in osteoporosis therapy

C Cheng, K Wentworth… - Annual Review of …, 2020 - annualreviews.org
Current osteoporosis medications reduce fractures significantly but have rare and serious
adverse effects (osteonecrosis of the jaw, atypical femoral fractures) that may limit their …