Cancer remains a serious threat to human health owing to the lack of effective treatments.
Photodynamic therapy (PDT) has emerged as a promising non-invasive cancer treatment …

Prostate cancer remains the most prevalent cancer among men worldwide. This cancer is
hormone-dependent; therefore, androgen, estrogen, and their receptors play an important …

CBP/p300 are critical transcriptional coactivators of the androgen receptor (AR) and are
promising cancer therapeutic targets. Herein, we report the discovery of highly potent …

Simple Summary Chemotherapy is the first line of treatment for malignant tumors. However,
recent discoveries have shown that a relapse and the formation of metastatic disease could …

Prostate cancer is well known to be dependent on the androgen receptor (AR) for growth
and survival. Thus, AR is the main pharmacological target to treat this disease. However …

Hormonal therapies including androgen deprivation therapy and androgen receptor (AR)
pathway inhibitors such as abiraterone and enzalutamide have been widely used to treat …

Prostate cancer (PCa) is the most prevalent malignancy of the male genitourinary system,
and its etiology suggests that genetics is an essential risk factor for its development and …

Prostate cancer (PCa) is witnessing a concerning rise in incidence annually, with the
androgen receptor (AR) emerging as a pivotal contributor to its growth and progression …

Androgen receptor (AR) is a key member of nuclear hormone receptors with the longest
intrinsically disordered N-terminal domain in its protein family. There are four mono-amino …

Multivalency is an attractive strategy for effective binding to target protein. Bromodomain and
extra-terminal (BET) family features two tandem bromodomains (BD1, BD2), which are …