Nicotinamide adenine dinucleotide (NAD+) and its metabolites function as critical regulators
to maintain physiologic processes, enabling the plastic cells to adapt to environmental …

Dengue is a mosquito-borne viral disease (arboviral) caused by the Dengue virus. It is one
of the prominent public health problems in tropical and subtropical regions with no effective …

Dengue is widespread throughout the tropics and local spatial variation in dengue virus
transmission is strongly influenced by rainfall, temperature, urbanization and distribution of …

Apoptosis is a physiological process critical for organ development, tissue homeostasis, and
elimination of defective or potentially dangerous cells in complex organisms. Apoptosis can …

Dengue viral antigens have been demonstrated in several types of naturally infected human
tissues, but little is known of whether these same tissues have detectable viral RNA. We …

Nuclear factor-κB (NF-κB) is a ubiquitous transcription factor that governs the expression of
genes encoding cytokines, chemokines, growth factors, cell adhesion molecules, and some …

During their lifetime, cells encounter many life or death situations that challenge their very
own existence. Their survival depends on the interplay within a complex yet precisely …

▪ Abstract Successful viral replication requires not only the efficient production and spread of
progeny, but also evasion of host defense mechanisms that limit replication by killing …

The dengue virus can infect many cell types and cause diverse clinical and pathological
effects. We describe clinical and experimental observations that suggest that liver …

Dengue hemorrhagic fever and dengue shock syndrome (DHF/DSS) are severe
complications of secondary dengue virus (DV) infection. Vascular leakage, hemorrhagic …