Dopamine receptor subtypes, physiology and pharmacology: new ligands and concepts in schizophrenia
JC Martel, S Gatti McArthur - Frontiers in pharmacology, 2020 - frontiersin.org
Dopamine receptors are widely distributed within the brain where they play critical
modulator roles on motor functions, motivation and drive, as well as cognition. The …
modulator roles on motor functions, motivation and drive, as well as cognition. The …
Critical neurotransmitters in the neuroimmune network
TW Hodo, MTP De Aquino, A Shimamoto… - Frontiers in …, 2020 - frontiersin.org
Immune cells rely on cell-cell communication to specify and fine-tune their responses. They
express an extensive network of cell communication modes, including a vast repertoire of …
express an extensive network of cell communication modes, including a vast repertoire of …
Biased signaling due to oligomerization of the G protein-coupled platelet-activating factor receptor
J Liu, H Tang, C Xu, S Zhou, X Zhu, Y Li… - Nature …, 2022 - nature.com
G protein-coupled receptors (GPCRs) are important drug targets that mediate various
signaling pathways by activating G proteins and engaging β-arrestin proteins. Despite its …
signaling pathways by activating G proteins and engaging β-arrestin proteins. Despite its …
The endocannabinoid system as a target in cancer diseases: are we there yet?
The endocannabinoid system (ECS) has been placed in the anti-cancer spotlight in the last
decade. The immense data load published on its dual role in both tumorigenesis and …
decade. The immense data load published on its dual role in both tumorigenesis and …
GPCR heteromers: An overview of their classification, function and physiological relevance
G protein-coupled receptors (GPCRs) are capable of interacting to form higher order
structures such as homomers and heteromers. Heteromerisation in particular has …
structures such as homomers and heteromers. Heteromerisation in particular has …
Receptor-receptor interactions as a widespread phenomenon: novel targets for drug development?
The discovery of receptor-receptor interactions (RRI) has expanded our understanding of
the role that G protein-coupled receptors (GPCRs) play in intercellular communication. The …
the role that G protein-coupled receptors (GPCRs) play in intercellular communication. The …
A2AR-D2R heteroreceptor complexes in cocaine reward and addiction
DO Borroto-Escuela, K Wydra, M Filip, K Fuxe - Trends in Pharmacological …, 2018 - cell.com
The concept of allosteric receptor–receptor interactions in G protein-coupled receptor homo-
and heteroreceptor complexes in which they physically interact provides a new dimension to …
and heteroreceptor complexes in which they physically interact provides a new dimension to …
Oligomeric receptor complexes and their allosteric receptor-receptor interactions in the plasma membrane represent a new biological principle for integration of …
DO Borroto-Escuela, K Fuxe - Frontiers in molecular neuroscience, 2019 - frontiersin.org
G protein-coupled receptors (GPCRs) not only exist as monomers but also as homomers
and heteromers in which allosteric receptor-receptor interactions take place, modulating the …
and heteromers in which allosteric receptor-receptor interactions take place, modulating the …
Allosteric Interactions between Adenosine A2A and Dopamine D2 Receptors in Heteromeric Complexes: Biochemical and Pharmacological Characteristics, and …
K Prasad, EFJ de Vries, PH Elsinga… - International Journal of …, 2021 - mdpi.com
Adenosine and dopamine interact antagonistically in living mammals. These interactions are
mediated via adenosine A2A and dopamine D2 receptors (R). Stimulation of A2AR inhibits …
mediated via adenosine A2A and dopamine D2 receptors (R). Stimulation of A2AR inhibits …
Adenosine heteroreceptor complexes in the basal ganglia are implicated in Parkinson's disease and its treatment
DO Borroto-Escuela, K Fuxe - Journal of neural transmission, 2019 - Springer
The adenosine homo, iso and heteroreceptor complexes in the basal ganglia play a highly
significant role in modulating the indirect and direct pathways and the striosomal projections …
significant role in modulating the indirect and direct pathways and the striosomal projections …