HIV‐1 transmitted drug resistance surveillance: shifting trends in study design and prevalence estimates

SY Rhee, SG Kassaye, G Barrow… - Journal of the …, 2020 - Wiley Online Library
Introduction HIV‐1 transmitted drug resistance (TDR) prevalence increased during the initial
years of the antiretroviral therapy (ART) global scale‐up. Few studies have examined recent …

HIV-1 Drug Resistance Detected by Next-Generation Sequencing among ART-Naïve Individuals: A Systematic Review and Meta-Analysis

F Ouyang, D Yuan, W Zhai, S Liu, Y Zhou, H Yang - Viruses, 2024 - mdpi.com
Background: There are an increasing number of articles focused on the prevalence and
clinical impact of pretreatment HIV drug resistance (PDR) detected by Sanger sequencing …

Novel HLA class I associations with HIV-1 control in a unique genetically admixed population

H Valenzuela-Ponce, S Alva-Hernández… - Scientific reports, 2018 - nature.com
Associations between HLA class I alleles and HIV progression in populations exhibiting
Amerindian and Caucasian genetic admixture remain understudied. Using univariable and …

Analysis of unusual and signature APOBEC-mutations in HIV-1 pol next-generation sequences

PL Tzou, SL Kosakovsky Pond, S Avila-Rios… - PLoS …, 2020 - journals.plos.org
Introduction At low mutation-detection thresholds, next generation sequencing (NGS) for HIV-
1 genotypic resistance testing is susceptible to artifactual detection of mutations arising from …

HIV drug resistance in HIV positive individuals under antiretroviral treatment in Shandong Province, China

B Lin, X Sun, S Su, C Lv, X Zhang, L Lin, R Wang, J Fu… - PloS one, 2017 - journals.plos.org
The efficacy of antiretroviral drugs is limited by the development of drug resistance.
Therefore, it is important to examine HIV drug resistance following the nationwide …

HIV pretreatment drug resistance trends in three geographic areas of Mexico

C García-Morales, D Tapia-Trejo… - Journal of …, 2017 - academic.oup.com
Background Pretreatment drug resistance (PDR) levels to NNRTI approaching 10% have
recently been reported in Mexico. However, subnational differences may exist in PDR …

Identification of major routes of HIV transmission throughout Mesoamerica

A Chaillon, S Avila-Ríos, JO Wertheim, A Dennis… - Infection, Genetics and …, 2017 - Elsevier
Background Migration and travel are major drivers of the spread of infectious diseases.
Geographic proximity and a common language facilitate travel and migration in …

Establishment and application of a method of tagged-amplicon deep sequencing for low-abundance drug resistance in HIV-1

Y Li, L Han, Y Wang, X Wang, L Jia, J Li, J Han… - Frontiers in …, 2022 - frontiersin.org
In the latest HIV-1 global drug resistance report released by WHO, countries are advised to
strengthen pre-treatment monitoring of drug resistance in AIDS patients. In this study, we …

High levels of pretreatment and acquired HIV drug resistance in Nicaragua: Results from the first nationally representative survey, 2016

A Girón‐Callejas, C García‐Morales… - Journal of the …, 2019 - Wiley Online Library
Introduction A nationally representative HIV drug resistance (HIVDR) survey in Nicaragua
was conducted to estimate the prevalence of pretreatment HIVDR (PDR) among …

HIVseqDB: a portable resource for NGS and sample metadata integration for HIV-1 drug resistance analysis

A Ssekagiri, D Jjingo, N Bbosa… - Bioinformatics …, 2024 - academic.oup.com
Human immunodeficiency virus (HIV) remains a public health threat, with drug resistance
being a major concern in HIV treatment. Next-generation sequencing (NGS) is a powerful …