The prevalence and comorbidity of psychiatric disorders such as depression, anxiety and
insomnia are very common. These well-known forms of psychiatric disorders have been …

Abstract Context: Radix Bupleuri has been used in traditional Chinese medicine for over
2000 years with functions of relieving exterior syndrome, clearing heat, regulating liver-qi …

Depression is a devastating mood disorder that causes profound disability worldwide.
Despite the increasing number of antidepressant medications available, the treatment …

Abstract Ethnopharmacological relevance The genus Bupleurum (family Apiaceae),
comprising approximately 248 accepted species, is widely distributed and used in China …

This research aimed to explore the antidepressant components from Dendrobium officinale
flowers (DOF) aqueous extract and their mechanism. Multiple depressive models were …

Background Many studies about depression have focused on the dysfunctional synaptic
signaling in the hippocampus that drives the pathophysiology of depression. Radix Bupleuri …

Over the past decades, a number of phytochemicals have been reported to possess potent
pharmacological effects. Saikosaponins represent a group of oleanane derivatives, usually …

Recently, we reported that chronic nicotine significantly improved chronic stress-induced
impairments of cognition and the hippocampal synaptic plasticity in mice, however, the …

Dihydromyricetin (DMY), the major bioactive flavonoid ingredient extracted from the leaves
of Ampelopsis grossedentata (Hand.-Mazz) WT Wang, displays multiple pharmacological …

Depression is a commonly occurring neuropsychiatric disease with an increasing incidence
rate. Saikosaponin A (SA), a major bioactive component extracted from Radix Bupleuri …