Efferocytosis, ie, engulfment of dead cells by macrophages, is a crucial step during tissue
repair after an injury. Efferocytosis delineates the transition from the pro-inflammatory phase …

Skeletal muscle has an extraordinary regenerative capacity reflecting the rapid activation
and effective differentiation of muscle stem cells (MuSCs). In the course of muscle …

Aging is associated with nonresolving inflammation and tissue dysfunction. Resolvin D2
(RvD2) is a proresolving ligand that acts through the G-protein–coupled receptor called …

Specialized proresolving mediators (SPMs) actively limit inflammation and expedite its
resolution by modulating leukocyte recruitment and function. Here we profiled intramuscular …

Skeletal muscle ischemia reperfusion is very frequent in humans and results not only in
muscle destruction but also in multi-organ failure and death via systemic effects related to …

Significance: Inflammation increases during the aging process. It is linked to mitochondrial
dysfunction and increased reactive oxygen species (ROS) production. Mitochondrial …

Ischemic injury initiates a sterile inflammatory response that ultimately participates in the
repair and recovery of tissue perfusion. Macrophages are required for perfusion recovery …

After injury, the coordinated balance of pro-and anti-inflammatory factors in the
microenvironment contribute to skeletal muscle regeneration. However, the underlying …

Macrophages accumulate prominently in the visceral adipose tissue (VAT) of obese humans
and high fat diet (HFD) fed mice, and this is linked to insulin resistance and type II diabetes …

Introduction: Muscle wasting in Duchenne Muscular Dystrophy is caused by myofiber
fragility and poor regeneration that lead to chronic inflammation and muscle replacement by …