The hallmarks of cancer conceptualization is a heuristic tool for distilling the vast complexity
of cancer phenotypes and genotypes into a provisional set of underlying principles. As …

In recent years, exceptional technological advances have enabled the identification and
interrogation of rare circulating tumour cells (CTCs) from blood samples of patients, leading …

Genome editing holds great potential for cancer treatment due to the ability to precisely
inactivate or repair cancer-related genes. However, delivery of CRISPR/Cas to solid tumours …

The extracellular matrix (ECM) is one of the major components of tumors that plays multiple
crucial roles, including mechanical support, modulation of the microenvironment, and a …

Cancer-associated fibroblasts (CAFs) are a key component of the tumour microenvironment
with diverse functions, including matrix deposition and remodelling, extensive reciprocal …

Cells and tissues generate and are exposed to various mechanical forces that act across a
range of scales, from tissues to cells to organelles. Forces provide crucial signals to inform …

Mechanical forces shape cells and tissues during development and adult homeostasis. In
addition, they also signal to cells via mechanotransduction pathways to control cell …

Metastatic breast cancer cells disseminate to organs with a soft microenvironment. Whether
and how the mechanical properties of the local tissue influence their response to treatment …

Biophysical cues, such as mechanical properties, play a critical role in tissue growth and
homeostasis. During organ development and tissue injury repair, compressive and tensional …

Mechanical stimulation utilizing deep tissue-penetrating and focusable energy sources,
such as ultrasound and magnetic fields, is regarded as an emerging patient-friendly and …