A stromal Integrated Stress Response activates perivascular cancer-associated fibroblasts to drive angiogenesis and tumour progression
II Verginadis, H Avgousti, J Monslow, G Skoufos… - Nature cell …, 2022 - nature.com
Bidirectional signalling between the tumour and stroma shapes tumour aggressiveness and
metastasis. ATF4 is a major effector of the Integrated Stress Response, a homeostatic …
metastasis. ATF4 is a major effector of the Integrated Stress Response, a homeostatic …
Mechanoregulation of YAP and TAZ in cellular homeostasis and disease progression
Biophysical cues, such as mechanical properties, play a critical role in tissue growth and
homeostasis. During organ development and tissue injury repair, compressive and tensional …
homeostasis. During organ development and tissue injury repair, compressive and tensional …
The mesenchymal context in inflammation, immunity and cancer
Mesenchymal cells are mesoderm-derived stromal cells that are best known for providing
structural support to organs, synthesizing and remodeling the extracellular matrix (ECM) and …
structural support to organs, synthesizing and remodeling the extracellular matrix (ECM) and …
Brillouin microscopy: an emerging tool for mechanobiology
The role and importance of mechanical properties of cells and tissues in cellular function,
development and disease has widely been acknowledged, however standard techniques …
development and disease has widely been acknowledged, however standard techniques …
Fluids and their mechanics in tumour transit: shaping metastasis
Metastasis is a dynamic succession of events involving the dissemination of tumour cells to
distant sites within the body, ultimately reducing the survival of patients with cancer. To …
distant sites within the body, ultimately reducing the survival of patients with cancer. To …
Reduction of liver metastasis stiffness improves response to bevacizumab in metastatic colorectal cancer
Y Shen, X Wang, J Lu, M Salfenmoser, NM Wirsik… - Cancer cell, 2020 - cell.com
Tumors are influenced by the mechanical properties of their microenvironment. Using
patient samples and atomic force microscopy, we found that tissue stiffness is higher in liver …
patient samples and atomic force microscopy, we found that tissue stiffness is higher in liver …
Friend or foe? The elusive role of hepatic stellate cells in liver cancer
B Cogliati, CN Yashaswini, S Wang, D Sia… - Nature Reviews …, 2023 - nature.com
Liver fibrosis is a substantial risk factor for the development and progression of liver cancer,
which includes hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma …
which includes hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma …
Mechanical adaptability of tumor cells in metastasis
The most dangerous aspect of cancer lies in metastatic progression. Tumor cells will
successfully form life-threatening metastases when they undergo sequential steps along a …
successfully form life-threatening metastases when they undergo sequential steps along a …
Biophysics in tumor growth and progression: from single mechano-sensitive molecules to mechanomedicine
Evidence from physical sciences in oncology increasingly suggests that the interplay
between the biophysical tumor microenvironment and genetic regulation has significant …
between the biophysical tumor microenvironment and genetic regulation has significant …
The extracellular matrix viscoelasticity as a regulator of cell and tissue dynamics
A Elosegui-Artola - Current opinion in cell biology, 2021 - Elsevier
The extracellular matrix mechanical properties regulate processes in development, cancer,
and fibrosis. Among the distinct mechanical properties, the vast majority of research has …
and fibrosis. Among the distinct mechanical properties, the vast majority of research has …