Non-sexual implications of phosphodiesterase type 5 inhibitors
T Mostafa - Sexual Medicine Reviews, 2017 - academic.oup.com
Abstract Introduction Phosphodiesterase type 5 (PDE5) hydrolyses cyclic guanylate
monophosphate specifically to 5′ guanylate monophosphate, promoting corporeal …
monophosphate specifically to 5′ guanylate monophosphate, promoting corporeal …
cGMP signalling in dorsal root ganglia and the spinal cord: various functions in development and adulthood
H Schmidt, A Böttcher, T Gross… - British journal of …, 2022 - Wiley Online Library
Cyclic GMP (cGMP) is a second messenger that regulates numerous physiological and
pathophysiological processes. In recent years, more and more studies have uncovered …
pathophysiological processes. In recent years, more and more studies have uncovered …
Antinociceptive effect of tadalafil in various pain models: Involvement of opioid receptors and nitric oxide cyclic GMP pathway
MM Mehanna, S Domiati, HN Chmaisse… - Toxicology and applied …, 2018 - Elsevier
Nitric oxide has been proven to play an important role in nociception, accordingly, its
promoters, phosphodiesterase inhibitors have been investigated as pain response …
promoters, phosphodiesterase inhibitors have been investigated as pain response …
Design and synthesis of 3-aminophthalazine derivatives and structural analogues as PDE5 inhibitors: anti-allodynic effect against neuropathic pain in a mouse model
M Bollenbach, C Lugnier, M Kremer, E Salvat… - European Journal of …, 2019 - Elsevier
Neuropathic pain is a chronic pain caused by a lesion or disease affecting the
somatosensory nervous system. To date, no specific treatment has been developed to cure …
somatosensory nervous system. To date, no specific treatment has been developed to cure …
Molecular Mechanics Simulations and Experimental Investigation of the Effect of Tadalafil on Various Inflammatory Pain Mediators
Purpose: Tadalafil's exact analgesic mechanism is still unclear. The current study aimed to
elucidate this mechanism in an inflammatory pain model. Methods: Computer-assisted …
elucidate this mechanism in an inflammatory pain model. Methods: Computer-assisted …
[HTML][HTML] The synthetic peptide PnPP-19 induces peripheral antinociception via activation of NO/cGMP/KATP pathway: Role of eNOS and nNOS
ACN Freitas, GC Silva, DF Pacheco, AMC Pimenta… - Nitric oxide, 2017 - Elsevier
Background and purpose: The peptide PnPP-19, derived from the spider toxin PnTx2-6
(renamed as δ-CNTX-Pn1c), potentiates erectile function by activating the nitrergic system …
(renamed as δ-CNTX-Pn1c), potentiates erectile function by activating the nitrergic system …
Antinociceptive Effect of Lodenafil Carbonate in Rodent Models of Inflammatory Pain and Spinal Nerve Ligation-Induced Neuropathic Pain
MC Vieira, FBM Monte, B Eduardo Dematte… - Journal of pain …, 2021 - Taylor & Francis
Introduction New therapeutic alternatives for pain relief include the use of
phosphodiesterase-5 (PDE5) inhibitors, which could prevent the transmission of painful …
phosphodiesterase-5 (PDE5) inhibitors, which could prevent the transmission of painful …
[HTML][HTML] The regulation of sGC on the rat model of neuropathic pain is mediated by 5-HT1ARs and NO/cGMP pathway
Z Xu, B Yang, J Zhang, J Zheng - American Journal of Translational …, 2016 - ncbi.nlm.nih.gov
Inadequate management of neuropathic pain results in poor clinical outcomes and reduces
quality of life for the patient all over the world, but intricate interplay between wide variety of …
quality of life for the patient all over the world, but intricate interplay between wide variety of …
Repeated Dosing with NCX1404, a Nitric Oxide–Donating Pregabalin, Re-establishes Normal Nociceptive Responses in Mice with Streptozotocin-Induced Painful …
K Varani, F Vincenzi, M Targa, A Ravani, E Bastia… - … of Pharmacology and …, 2016 - ASPET
NCX1404 [(3 S)-5-methyl-3-(((1-(4-(nitrooxy) butanoyloxy) ethoxy) carbonylamino) methyl)
hexanoic acid] is a novel nitric oxide (NO)–donating pregabalin that is readily absorbed and …
hexanoic acid] is a novel nitric oxide (NO)–donating pregabalin that is readily absorbed and …
Analgesia additive interaction between tadalafil and morphine in an experimental animal model
Since both morphine and tadalafil have been proven to exert some of their analgesic activity
through modulation of the NO–cGMP pathway, the aim of the current study is to evaluate the …
through modulation of the NO–cGMP pathway, the aim of the current study is to evaluate the …